Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | MGAM | O43451 | 1/20 | 0.38 |
| ▸ | SI | P14410 | 1/20 | 0.38 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12787244 | 0.87 | ALDH1A1 (0.43) | ALDH1A1EPHX1POLBSMN1; SMN2GAA | |
| SCHEMBL18026348 | 0.85 | ALDH1A1 (0.47) | ALDH1A1EPHX1POLBSMN1; SMN2GAA | |
| SCHEMBL2757931 | 0.79 | ALDH1A1 (0.50) | ALDH1A1EPHX1POLBSMN1; SMN2GAA | |
| SCHEMBL29129821 | 0.79 | ALDH1A1 (0.36) | ALDH1A1GAAMGAMSIMGAM2 | |
| SCHEMBL18860307 | 0.79 | ALDH1A1 (0.44) | ALDH1A1EPHX1POLBSMN1; SMN2GAA | |
| SCHEMBL13618809 | 0.78 | MAPT (0.44) | ALDH1A1EPHX1POLBSMN1; SMN2GAA | |
| SCHEMBL1687263 | 0.78 | — | — | |
| SCHEMBL2412491 | 0.77 | ALDH1A1 (0.38) | ALDH1A1POLBSMN1; SMN2GAANPC1 | |
| SCHEMBL14902212 | 0.77 | KMT2A (0.35) | ALDH1A1GAAMGAMSIMGAM2 | |
| SCHEMBL19171550 | 0.77 | SMN1; SMN2 (0.50) | ALDH1A1EPHX1POLBSMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9977024-B2 | Targeted covalent probes and inhibitors of proteins containing redox-sensitive cysteines | THE SCRIPPS RESEARCH INSTITUTE (US) | 2018-05-22 | — | — | US | disclosed |
| US-9977024-B2 | Targeted covalent probes and inhibitors of proteins containing redox-sensitive cysteines | THE SCRIPPS RESEARCH INSTITUTE (US) | 2018-05-22 | — | — | US | disclosed |
| US-20170267698-A1 | NITROGEN-CONTAINING MACROCYCLIC CONJUGATES AS RADIOPHARMACEUTICALS | Clarity Pharmaceuticals Ltd (AU) | 2017-09-21 | — | — | US | disclosed |
| US-20170267699-A1 | NITROGEN-CONTAINING MACROCYCLIC CONJUGATES AS RADIOPHARMACEUTICALS | Clarity Pharmaceuticals Ltd (AU) | 2017-09-21 | — | — | US | disclosed |
| US-9701694-B2 | Nitrogen-containing macrocyclic conjugates as radiopharmaceuticals | THE UNIVERSITY OF MELBOURNE (AU) | 2017-07-11 | — | — | US | disclosed |
| US-20160195532-A1 | Targeted Covalent Probes and Inhibitors of Proteins Containing Redox-Sensitive Cysteines | THE SCRIPPS RESEARCH INSTITUTE | 2016-07-07 | — | — | US | disclosed |
| CN-103709054-B | Preparation method of DL-leucine | 广州天科生物科技有限公司 | 2016-06-29 | — | — | CN | disclosed |
| US-20140107125-A1 | HYDRAZONOPYRAZOLE DERIVATIVES AND THEIR USE AS THERAPEUTICS | DERMIRA (CANADA), INC. (US) | 2014-04-17 | — | — | US | disclosed |
| US-8445694-B2 | Hydrazonopyrazole derivatives and their use as therapeutics | DERMIRA (CANADA), INC. (US) | 2013-05-21 | — | — | US | disclosed |
| US-20110293517-A1 | Nitrogen-Containing Macrocyclic Conjugates As Radiopharmaceuticals | THE UNIVERSITY OF MELBOURNE (AU) | 2011-12-01 | — | — | US | disclosed |
| US-7875728-B2 | tert-butyl-[5-methyl-4-(phenylhydrazono)-4H-pyrazol-3-yl]amine; 4-(3-fluorophenylhydrazono)-5-methyl-2H-pyrazol-3-ylamine; demonstrate anti-proliferative activity, and may promote apoptosis in cells lacking normal regulation of cell cycle and death | Valocor Therapeutics, Inc. (CA) | 2011-01-25 | — | — | US | disclosed |
| US-20050272709-A1 | Immugenic compositions and diagnostic and therapeutic uses thereof | DERMIRA (CANADA), INC. | 2005-12-08 | — | — | US | disclosed |
| EP-0472438-B1 | Processes for the preparation of y-methacryloxypropylsilane compounds | TONEN CORP (JP) | 1996-12-18 | — | — | EP | disclosed |
| EP-0472438-A1 | Processes for the preparation of y-methacryloxypropylsilane compounds | Tonen Corporation (JP) | 1992-02-26 | — | — | EP | disclosed |
| EP-0266989-B1 | DIHYDROPYRIDINE ANTI-ALLERGIC AND ANTI-INFLAMMATORY AGENTS | Pfizer Limited (GB) | 1990-07-04 | — | — | EP | disclosed |
| US-4904671-A | ANTIARTHRITIC AGENTS; PLATELET ACTIVATING FACTOR | PFIZER INC. (US) | 1990-02-27 | — | — | US | disclosed |
| US-4866175-A | REACTING BENZOFUROXAN WITH MALONIC ESTER, CYANO(ESTER OR AMIDE), KETO(ESTER OR AMIDE), DIKETONE, MALONONITRILE, OR NITRO COMPOUND | RESEARCH CORPORATION (US) | 1989-09-12 | — | — | US | disclosed |
| US-4801598-A | Dihydropyridine anti-allergic and anti-inflammatory agents | PFIZER INC. (US) | 1989-01-31 | — | — | US | disclosed |
| EP-0266989-A2 | Dihydropyridine anti-allergic and anti-inflammatory agents | Pfizer Limited (GB) | 1988-05-11 | — | — | EP | disclosed |
| US-4343942-A | BACTERICIDES | RESEARCH CORPORATION (US) | 1982-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140107125-A1 | HYDRAZONOPYRAZOLE DERIVATIVES AND THEIR USE AS THERAPEUTICS | CDK4, CCNI, BCL2 | ALDH1A1 1614/4885EPHX1 3006/4885POLB 1521/4885 |
| US-20170267699-A1 | NITROGEN-CONTAINING MACROCYCLIC CONJUGATES AS RADIOPHARMACEUTICALS | NCL, NUDC, C3AR1 | ALDH1A1 2338/4885EPHX1 3846/4885POLB 3039/4885 |
| US-20050272709-A1 | Immugenic compositions and diagnostic and therapeutic uses thereof | MKI67, CDK4, CCNC | ALDH1A1 3393/4885EPHX1 3859/4885POLB 1409/4885 |
| US-20110293517-A1 | Nitrogen-Containing Macrocyclic Conjugates As Radiopharmaceuticals | NCL, NUDC, C3AR1 | ALDH1A1 2338/4885EPHX1 3846/4885POLB 3039/4885 |
| US-20170267698-A1 | NITROGEN-CONTAINING MACROCYCLIC CONJUGATES AS RADIOPHARMACEUTICALS | NCL, NUDC, C3AR1 | ALDH1A1 2338/4885EPHX1 3846/4885POLB 3039/4885 |
| US-20160195532-A1 | Targeted Covalent Probes and Inhibitors of Proteins Containing Redox-Sensitive Cysteines | PTMS, RSU1, QSOX1 | ALDH1A1 3255/4885EPHX1 1871/4885POLB 4277/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.