Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.38 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.34 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.33 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.33 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27520063 | 0.98 | ALOX5 (0.37) | ALOX5GRM2GRM3PARP15PARP10 | |
| SCHEMBL27766894 | 0.94 | ALOX5 (0.37) | ALOX5GRM2GRM3PARP15PARP10 | |
| SCHEMBL27493732 | 0.90 | THRA (0.39) | ALOX5PARP15PARP10ATM | |
| SCHEMBL27593151 | 0.84 | NR1H2 (0.38) | ATM | |
| SCHEMBL27593149 | 0.84 | NR1H2 (0.38) | ATM | |
| SCHEMBL27593029 | 0.84 | THRA (0.35) | ATM | |
| SCHEMBL28794950 | 0.84 | NR1H2 (0.38) | ATM | |
| SCHEMBL27611217 | 0.84 | PLG (0.41) | ATM | |
| SCHEMBL27594438 | 0.84 | THRA (0.35) | ATM | |
| SCHEMBL27611212 | 0.84 | THRA (0.35) | ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109476643-A | PYRAZOLYLAMINOBENZIMIDAZOLE DERIVATIVES AS JAK INHIBITORS | 伊莱利利公司 | 2019-03-15 | — | — | CN | disclosed |
| CN-107108597-A | Dopamine D3 receptor antagonist compounds | 英立维尔英国有限公司 | 2017-08-29 | — | — | CN | disclosed |
| CN-105001226-A | Tricycle heterocyclic compounds and JAK inhibitors | NISSAN CHEMICAL IND LTD | 2015-10-28 | — | — | CN | disclosed |
| CN-104945374-A | Conjugates for the prevention or treatment of nicotine addiction | PFIZER VACCINES LLC | 2015-09-30 | — | — | CN | disclosed |
| CN-104918945-A | Tricyclic fused thiophene derivatives as JAK inhibitors | INCYTE CORP | 2015-09-16 | — | — | CN | disclosed |
| CN-104147011-A | Uses of pyridine-diketone serving as PDE4 inhibitor for treating eye diseases | ASTRAZENECA AB | 2014-11-19 | — | — | CN | disclosed |
| CN-102427853-B | Protease Inhibitors | ORION CORP | 2014-11-05 | — | — | CN | disclosed |
| CN-103732597-A | Tricyclic heterocyclic compounds and JAK inhibitors | NISSAN CHEMICAL IND LTD | 2014-04-16 | — | — | CN | disclosed |
| CN-103339134-A | Tricyclic pyrrolo derivatives, process for their preparation and their use as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL | 2013-10-02 | — | — | CN | disclosed |
| CN-101636388-B | 637 pyridopyrimidinediones as PDE4 inhibitors | ASTRAZENECA AB | 2013-09-18 | — | — | CN | disclosed |
| CN-102317282-A | Hetero ring derivative | ASTELLAS PHARMA INC | 2012-01-11 | — | — | CN | disclosed |
| CN-102292323-A | Aryl methyl benzoquinazolinone M1 receptor positive allosteric modulators | — | 2011-12-21 | — | — | CN | disclosed |
| CN-102159547-A | Heterocyclic carboxamide compounds | ASTELLAS PHARMA INC | 2011-08-17 | — | — | CN | disclosed |
| CN-101636388-A | Compound 637: pyridopyrimidinediones as PDE4 inhibitors | ASTRAZENECA AB | 2010-01-27 | — | — | CN | disclosed |
| CN-101454318-A | Pyridopyrimidine derivatives and their use as pde4 inhibitors | ASTRAZENECA AB (SE) | 2009-06-10 | — | — | CN | disclosed |
| CN-101370812-A | Fused heterocyclic compound | TAKEDA PHARMACEUTICAL (JP) | 2009-02-18 | — | — | CN | disclosed |
| CN-101263110-A | Optically active diamine derivative and process for producing the same | DAIICHI SANKYO CO LTD (JP) | 2008-09-10 | — | — | CN | disclosed |
| CN-101258152-A | Pyridopyrimidine derivatives as PDE4 inhibitors for the treatment of inflammatory and immune diseases | ASTRAZENECA AB (SE) | 2008-09-03 | — | — | CN | disclosed |
| CN-1678616-A | Cephalosporins | SANDOZ AG (CH) | 2005-10-05 | — | — | CN | disclosed |
| EP-0701568-A1 | NEW PEPTIDE DERIVATIVES | Astra Aktiebolag (SE) | 1996-03-20 | — | — | EP | disclosed |