SCHEMBL9230351

SCHEMBL9230351

C=CC(=O)C(COC(=O)CCc1cc(-n2nc3ccccc3n2)c(O)c(C(C)(C)C)c1)COc1ccccc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 3/20 0.38
▸ NPC1 O15118 3/20 0.38
▸ RAB9A P51151 3/20 0.38
▸ MAPT P10636 2/20 0.38
▸ HPGD P15428 2/20 0.38
▸ TDP1 Q9NUW8 2/20 0.38
▸ KDM4E B2RXH2 2/20 0.38
▸ GAA P10253 4/20 0.34
▸ KMT2A Q03164 2/20 0.34
▸ MEN1 O00255 1/20 0.34
▸ MAOB P27338 3/20 0.34
▸ MAOA P21397 2/20 0.34
▸ ACHE P22303 1/20 0.33
▸ SMN1; SMN2 Q16637 2/20 0.32
▸ LMNA P02545 1/20 0.32
▸ AGTR1 P30556 1/20 0.32
▸ HTT P42858 1/20 0.32
▸ ALOX5 P09917 1/20 0.32
▸ NPSR1 Q6W5P4 1/20 0.30
▸ L3MBTL1 Q9Y468 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10471728 0.88 ALDH1A1 (0.37) ALDH1A1NPC1RAB9AMAPTHPGD
SCHEMBL10472398 0.87 KDM4E (0.41) ALDH1A1NPC1RAB9AMAPTHPGD
SCHEMBL9231365 0.86 MAOB (0.35) ALDH1A1NPC1RAB9AMAPTHPGD
SCHEMBL10470534 0.83 GAA (0.38) ALDH1A1NPC1RAB9AMAPTHPGD
SCHEMBL9230983 0.83 GAA (0.35) ALDH1A1NPC1RAB9AMAPTHPGD
SCHEMBL9227024 0.82 GAA (0.34) ALDH1A1NPC1RAB9AMAPTHPGD
SCHEMBL9871543 0.82 GAA (0.39) ALDH1A1NPC1RAB9AMAPTHPGD
SCHEMBL10470440 0.82 MAOB (0.34) ALDH1A1NPC1RAB9AMAPTHPGD
SCHEMBL9869698 0.81 GAA (0.38) ALDH1A1NPC1RAB9AGAAKMT2A
SCHEMBL10135978 0.81 ALOX5 (0.44) ALDH1A1NPC1RAB9ATDP1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5476882-A Containing 2,2,6,6-tetraalkylpiperidine derivative CIBA-GEIGY CORPORATION (US) 1995-12-19 — — US disclosed
US-5274016-A Crosslinked polyolefin core and stabilizer of a 2,2,6,6-tetramethylpiperidine derivative having at least one ethylenic double bone CIBA-GEIGY CORPORATION (US) 1993-12-28 — — US disclosed
EP-0296391-B1 LIGHT-STABILIZED POLYMER MICROPARTICLES CONTAINING EPOXY GROUPS CIBA-GEIGY AG (CH) 1993-07-07 — — EP disclosed
EP-0226538-B1 LIGHT STABILIZED POLYMER MICROPARTICLES Ciba SC Holding AG (CH) 1991-09-11 — — EP disclosed
US-4894399-A Light-stabilized polymer microparticles containing epoxy groups CIBA-GEIGY CORPORATION (US) 1990-01-16 — — US disclosed
EP-0133164-B1 COMPOUNDS WHICH CAN BE COPOLYMERISED CIBA-GEIGY AG (CH) 1988-12-14 — — EP disclosed
EP-0133164-A2 Compounds which can be copolymerised CIBA-GEIGY AG (CH) 1985-02-13 — — EP disclosed
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