Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 10/20 | 0.57 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 5/20 | 0.57 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.51 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 12/20 | 0.57 |
| ▸ | DRD3 | P35462 | 10/20 | 0.57 |
| ▸ | HTR2A | P28223 | 9/20 | 0.57 |
| ▸ | TMEM97 | Q5BJF2 | 5/20 | 0.57 |
| ▸ | DRD1 | P21728 | 3/20 | 0.57 |
| ▸ | DRD5 | P21918 | 3/20 | 0.57 |
| ▸ | HRH1 | P35367 | 5/20 | 0.55 |
| ▸ | HTR2C | P28335 | 3/20 | 0.52 |
| ▸ | DRD4 | P21917 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28918989 | 0.98 | DRD2 (0.58) | DRD2DRD3HTR1AHTR2ATMEM97 | |
| SCHEMBL9757260 | 0.93 | DRD2 (0.61) | DRD2DRD3HTR1AHTR2ATMEM97 | |
| SCHEMBL8011318 | 0.88 | DRD2 (0.69) | DRD2DRD3HTR1AHTR2ATMEM97 | |
| SCHEMBL27360459 | 0.83 | DRD2 (0.60) | DRD2DRD3HTR1AHTR2ATMEM97 | |
| SCHEMBL2095204 | 0.81 | DRD2 (0.58) | DRD2DRD3HTR1AHTR2ATMEM97 | |
| SCHEMBL8223307 | 0.81 | KDM4E (0.62) | DRD2DRD3HTR1AHTR2ATMEM97 | |
| SCHEMBL5178761 | 0.81 | DRD2 (0.65) | DRD2DRD3HTR1AHTR2ATMEM97 | |
| SCHEMBL7653085 | 0.81 | CYP2D6 (0.70) | DRD2DRD3HTR1AHTR2ATMEM97 | |
| SCHEMBL10661045 | 0.81 | DRD2 (0.58) | DRD2DRD3HTR1AHTR2ATMEM97 | |
| SCHEMBL8334022 | 0.81 | DRD2 (0.58) | DRD2DRD3HTR1AHTR2ATMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661266-A1 | Substituted cyclic amine compounds as 5HT2 antagonists | TOA EIYO LTD. (JP) | 1995-07-05 | — | — | EP | disclosed |