Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 10/20 | 0.61 |
| ▸ | HTR1A | P08908 | 9/20 | 0.61 |
| ▸ | DRD3 | P35462 | 8/20 | 0.61 |
| ▸ | HTR2A | P28223 | 7/20 | 0.61 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.61 |
| ▸ | DRD1 | P21728 | 3/20 | 0.61 |
| ▸ | DRD5 | P21918 | 3/20 | 0.61 |
| ▸ | HRH1 | P35367 | 3/20 | 0.56 |
| ▸ | DRD4 | P21917 | 3/20 | 0.56 |
| ▸ | HTR2C | P28335 | 2/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL9230634 | 0.93 | DRD2 (0.57) | DRD2HTR1ADRD3HTR2ATMEM97 | |
| SCHEMBL8011318 | 0.91 | DRD2 (0.69) | DRD2HTR1ADRD3HTR2ATMEM97 | |
| SCHEMBL3197906 | 0.83 | CYP2D6 (0.63) | DRD2HTR1ADRD3HTR2ATMEM97 | |
| SCHEMBL9757322 | 0.83 | HTR1A (0.61) | DRD2HTR1ADRD3HTR2ATMEM97 | |
| SCHEMBL13875126 | 0.83 | KDM4E (0.69) | DRD2HTR1ADRD3HTR2ATMEM97 | |
| SCHEMBL2097950 | 0.83 | DRD2 (0.61) | DRD2HTR1ADRD3HTR2ATMEM97 | |
| SCHEMBL16666842 | 0.83 | KDM4E (0.69) | DRD2HTR1ADRD3HTR2ATMEM97 | |
| SCHEMBL2090615 | 0.82 | DRD2 (0.59) | DRD2HTR1ADRD3HTR2ATMEM97 | |
| SCHEMBL2095204 | 0.81 | DRD2 (0.58) | DRD2HTR1ADRD3HTR2ATMEM97 | |
| SCHEMBL7653085 | 0.81 | CYP2D6 (0.70) | DRD2HTR1ADRD3HTR2ATMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5036075-A | Serotonin antagonists | RHONE-POULENC SANTE (FR) | 1991-07-30 | — | — | US | disclosed |
| US-5021420-A | Antiserotonine agents; central nervous system, gastroin-testinal and cardiovascular disorders | RHONE-POULENC SANTE (FR) | 1991-06-04 | — | — | US | disclosed |