Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | TOP2A | P11388 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8852294 | 0.88 | ALOX5 (0.48) | TDP1TOP2AALDH1A1ALOX5LTA4H | |
| SCHEMBL8852249 | 0.81 | ALDH1A1 (0.51) | TDP1LMNAALDH1A1LTA4HPOLB | |
| SCHEMBL3851800 | 0.79 | TDP1 (0.82) | TDP1LMNAALDH1A1ALOX5APP | |
| SCHEMBL8851560 | 0.79 | ALOX5 (0.52) | TDP1TOP2AALDH1A1ALOX5LTA4H | |
| SCHEMBL13557789 | 0.78 | TDP1 (0.68) | TDP1LMNATOP2AALDH1A1ALOX5 | |
| SCHEMBL3954435 | 0.76 | TDP1 (0.66) | TDP1LMNATOP2AALOX5SMN1; SMN2 | |
| SCHEMBL650649 | 0.75 | ALDH1A1 (0.63) | TDP1LMNAALDH1A1ALOX5SMN1; SMN2 | |
| SCHEMBL10031001 | 0.75 | ALDH1A1 (0.54) | TDP1LMNATOP2AALDH1A1ALOX5 | |
| SCHEMBL16672928 | 0.75 | TDP1 (0.54) | TDP1LMNATOP2AALDH1A1POLB | |
| SCHEMBL17578861 | 0.75 | TDP1 (0.64) | TDP1LMNATOP2AALOX5MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0645390-A1 | Trisubstituted pyrimido 5,4-d pyrimidines for modulating multidrug resistance, drugs containing these compounds and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1995-03-29 | — | — | EP | disclosed |