Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.62 |
| ▸ | GAA | P10253 | 4/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | BRAF | P15056 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | RAF1 | P04049 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.50 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | LGMN | Q99538 | 2/20 | 0.49 |
| ▸ | NSD2 | O96028 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL519230 | 0.86 | MAPT (0.69) | MAPTGAASMN1; SMN2BRAFALDH1A1 | |
| SCHEMBL3341828 | 0.83 | ALDH1A1 (0.70) | MAPTGAASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL3885064 | 0.81 | KMT2A (0.53) | MAPTGAASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL14280213 | 0.81 | LGMN (0.71) | MAPTGAASMN1; SMN2BRAFALDH1A1 | |
| SCHEMBL13182855 | 0.80 | LGMN (0.64) | MAPTGAASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL429632 | 0.80 | MAPT (0.62) | MAPTGAASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL2302770 | 0.79 | LGMN (0.50) | MAPTGAASMN1; SMN2BRAFALDH1A1 | |
| SCHEMBL19088579 | 0.79 | NPSR1 (0.58) | MAPTALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL20349156 | 0.79 | ALDH1A1 (0.49) | MAPTGAASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL27742410 | 0.79 | ALDH1A1 (0.52) | MAPTGAASMN1; SMN2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2828339-B1 | CARBOXYLATE DYES | MILLIKEN & CO (US) | 2018-10-31 | — | — | EP | disclosed |
| US-9187717-B2 | Carboxylate dyes | MILLIKEN & COMPANY (US) | 2015-11-17 | — | — | US | disclosed |
| US-20150099869-A1 | Carboxylate Dyes | MILLIKEN & COMPANY | 2015-04-09 | — | — | US | disclosed |
| EP-2828339-A1 | CARBOXYLATE DYES | Milliken & Company (US) | 2015-01-28 | — | — | EP | disclosed |
| EP-2828340-A1 | LAUNDRY CARE COMPOSITIONS CONTAINING DYES | The Procter & Gamble Company (US) | 2015-01-28 | — | — | EP | disclosed |
| US-20140107125-A1 | HYDRAZONOPYRAZOLE DERIVATIVES AND THEIR USE AS THERAPEUTICS | DERMIRA (CANADA), INC. (US) | 2014-04-17 | — | — | US | disclosed |
| WO-2013142486-A1 | LAUNDRY CARE COMPOSITIONS CONTAINING DYES | THE PROCTER & GAMBLE COMPANY (US) | 2013-09-26 | — | — | WO | disclosed |
| WO-2013142495-A1 | CARBOXYLATE DYES | MILLIKEN & COMPANY (US) | 2013-09-26 | — | — | WO | disclosed |
| US-8445694-B2 | Hydrazonopyrazole derivatives and their use as therapeutics | DERMIRA (CANADA), INC. (US) | 2013-05-21 | — | — | US | disclosed |
| US-20110237783-A1 | HYDRAZONOPYRAZOLE DERIVATIVES AND THEIR USE AS THERAPEUTICS | Valocor Therapeutics, Inc. (CA) | 2011-09-29 | — | — | US | disclosed |
| US-7875728-B2 | tert-butyl-[5-methyl-4-(phenylhydrazono)-4H-pyrazol-3-yl]amine; 4-(3-fluorophenylhydrazono)-5-methyl-2H-pyrazol-3-ylamine; demonstrate anti-proliferative activity, and may promote apoptosis in cells lacking normal regulation of cell cycle and death | Valocor Therapeutics, Inc. (CA) | 2011-01-25 | — | — | US | disclosed |
| US-7105503-B2 | Pyrazole compounds | QLT INC. (CA) | 2006-09-12 | — | — | US | disclosed |
| US-20050272709-A1 | Immugenic compositions and diagnostic and therapeutic uses thereof | DERMIRA (CANADA), INC. | 2005-12-08 | — | — | US | disclosed |
| EP-1450791-A1 | HYDRAZONOPYRAZOLE DERIVATIVES AND THEIR USE AS THERAPEUTICS | Kinetek Pharmaceuticals, Inc. (CA) | 2004-09-01 | — | — | EP | disclosed |
| WO-2003045379-A1 | HYDRAZONOPYRAZOLE DERIVATIVES AND THEIR USE AS THERAPEUTICS | KINETEK PHARMACEUTICALS, INC. (CA) | 2003-06-05 | — | — | WO | disclosed |
| US-20030060453-A1 | Pyrazole compounds | DERMIRA (CANADA), INC. | 2003-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110237783-A1 | HYDRAZONOPYRAZOLE DERIVATIVES AND THEIR USE AS THERAPEUTICS | CDK4, CCNI, BCL2 | MAPT 4573/4885GAA 1621/4885SMN1; SMN2 4161/4885 |
| US-20140107125-A1 | HYDRAZONOPYRAZOLE DERIVATIVES AND THEIR USE AS THERAPEUTICS | CDK4, CCNI, BCL2 | MAPT 4573/4885GAA 1621/4885SMN1; SMN2 4161/4885 |
| US-20050272709-A1 | Immugenic compositions and diagnostic and therapeutic uses thereof | MKI67, CDK4, CCNC | MAPT 4000/4885GAA 2285/4885SMN1; SMN2 2243/4885 |
| US-20030060453-A1 | Pyrazole compounds | CCNC, MKI67, CDC25C | MAPT 4486/4885GAA 1927/4885SMN1; SMN2 3557/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.