Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 known ✓ | P00734 | 5/20 | 0.51 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 9/20 | 0.51 |
| ▸ | KLK1 | P06870 | 6/20 | 0.51 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.43 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.43 |
| ▸ | HPN | P05981 | 1/20 | 0.43 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | HGFAC | Q04756 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | SLC47A2 | Q86VL8 | 1/20 | 0.43 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ACR | P10323 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9232530 | 1.00 | PRSS1 (0.51) | PRSS1KLK1F2SLC22A2TMPRSS2 | |
| SCHEMBL9230097 | 0.91 | PRSS1 (0.42) | PRSS1KLK1F2KMT2AACR | |
| SCHEMBL9232848 | 0.91 | PRSS1 (0.42) | PRSS1KLK1F2KMT2AACR | |
| SCHEMBL9235287 | 0.90 | ACR (0.42) | PRSS1KLK1F2KMT2AACR | |
| SCHEMBL9231884 | 0.89 | PRSS1 (0.44) | PRSS1KLK1F2KMT2AACR | |
| SCHEMBL9231727 | 0.89 | KMT2A (0.42) | PRSS1KLK1F2KMT2AACR | |
| SCHEMBL9232990 | 0.89 | KMT2A (0.42) | PRSS1KLK1F2KMT2AACR | |
| SCHEMBL9232825 | 0.89 | KMT2A (0.46) | PRSS1KLK1F2KMT2AACR | |
| SCHEMBL9234347 | 0.89 | KMT2A (0.46) | PRSS1KLK1F2KMT2AACR | |
| SCHEMBL9235721 | 0.89 | KMT2A (0.46) | PRSS1KLK1F2KMT2AACR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0673924-A1 | PROPIONIC ACID DERIVATIVE | TEIKOKU CHEMICAL INDUSTRY CO., LTD. (JP) | 1995-09-27 | — | — | EP | disclosed |