Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.41 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.41 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9238875 | 1.00 | ALDH1A1 (0.41) | ALDH1A1MTORPMP22SMN1; SMN2CYP3A4 | |
| SCHEMBL9238873 | 1.00 | ALDH1A1 (0.41) | ALDH1A1MTORPMP22SMN1; SMN2CYP3A4 | |
| SCHEMBL9237851 | 0.83 | ALDH1A1 (0.39) | ALDH1A1MTORPMP22SMN1; SMN2CYP3A4 | |
| SCHEMBL9237845 | 0.83 | ALDH1A1 (0.39) | ALDH1A1MTORPMP22SMN1; SMN2CYP3A4 | |
| SCHEMBL12747839 | 0.82 | CTH (0.39) | ALDH1A1SMN1; SMN2CYP3A4HDAC1HDAC8 | |
| SCHEMBL9232447 | 0.81 | TBXAS1 (0.45) | ALDH1A1CYP3A4ALOX15KDM4EMAPT | |
| SCHEMBL9232445 | 0.81 | TBXAS1 (0.45) | ALDH1A1CYP3A4ALOX15KDM4EMAPT | |
| SCHEMBL10511888 | 0.80 | ALDH1A1 (0.55) | ALDH1A1MTORPMP22SMN1; SMN2CYP3A4 | |
| SCHEMBL10511886 | 0.80 | ALDH1A1 (0.55) | ALDH1A1MTORPMP22SMN1; SMN2CYP3A4 | |
| SCHEMBL22778040 | 0.75 | CTH (0.39) | ALDH1A1SMN1; SMN2CYP3A4CYP2C9NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0339046-B1 | LEUKOTRIENE B 4 ANALOGS | UPJOHN CO (US) | 1995-02-15 | — | — | EP | disclosed |
| US-5116981-A | Antiinflammatory leukotriene B4 analogs | THE UPJOHN COMPANY (US) | 1992-05-26 | — | — | US | disclosed |
| EP-0339046-A1 | LEUKOTRIENE B 4? ANALOGS. | UPJOHN CO (US) | 1989-11-02 | — | — | EP | disclosed |
| WO-1988005045-A1 | LEUKOTRIENE B4 ANALOGS | THE UPJOHN COMPANY (US) | 1988-07-14 | — | — | WO | disclosed |