Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 2/20 | 0.42 |
| ▸ | LTA4H | P09960 | 3/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | LSS | P48449 | 3/20 | 0.39 |
| ▸ | BCHE | P06276 | 4/20 | 0.38 |
| ▸ | ACHE | P22303 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.36 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9237366 | 1.00 | MAPT (0.42) | MAPTALDH1A1FAAHLTA4HGSK3B | |
| Fumaric Acid SCHEMBL9236902 | 0.91 | GAA (0.46) | MAPTALDH1A1FAAHLTA4HLSS | |
| Maleic Acid SCHEMBL9236897 | 0.91 | GAA (0.46) | MAPTALDH1A1FAAHLTA4HLSS | |
| SCHEMBL9876908 | 0.91 | ALDH1A1 (0.51) | MAPTALDH1A1FAAHLTA4HGSK3B | |
| Fumaric Acid SCHEMBL9232176 | 0.90 | GSK3B (0.42) | ALDH1A1GSK3BLSSBCHEACHE | |
| Maleic Acid SCHEMBL9232171 | 0.90 | GSK3B (0.42) | ALDH1A1GSK3BLSSBCHEACHE | |
| Fumaric Acid SCHEMBL9234273 | 0.87 | LSS (0.41) | ALDH1A1GSK3BLSSBCHEACHE | |
| Maleic Acid SCHEMBL9236899 | 0.87 | GAA (0.47) | MAPTALDH1A1LTA4HLSSBCHE | |
| Fumaric Acid SCHEMBL9236905 | 0.87 | GAA (0.47) | MAPTALDH1A1LTA4HLSSBCHE | |
| Fumaric Acid SCHEMBL9234267 | 0.87 | LSS (0.41) | ALDH1A1GSK3BLSSBCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0641564-A1 | OPTICALLY ACTIVE CONDENSED PYRAZOLE COMPOUND FOR USE IN TREATING THROMBOCYTOPENIA AND ERYTHROPENIA | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1995-03-08 | — | — | EP | disclosed |