Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.38 |
| ▸ | EGFR known ✓ | P00533 | 1/20 | 0.36 |
| ▸ | JAK3 known ✓ | P52333 | 1/20 | 0.36 |
| ▸ | BTK known ✓ | Q06187 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | LSS | P48449 | 3/20 | 0.41 |
| ▸ | BCHE | P06276 | 4/20 | 0.40 |
| ▸ | ACHE | P22303 | 4/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.37 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL9232171 | 1.00 | GSK3B (0.42) | GSK3BLSSBCHEACHEESR1 | |
| Fumaric Acid SCHEMBL9237366 | 0.90 | MAPT (0.42) | GSK3BLSSBCHEACHEALDH1A1 | |
| Fumaric Acid SCHEMBL9237361 | 0.90 | MAPT (0.42) | GSK3BLSSBCHEACHEALDH1A1 | |
| Fumaric Acid SCHEMBL9234273 | 0.90 | LSS (0.41) | GSK3BLSSBCHEACHEHRH1 | |
| Fumaric Acid SCHEMBL9234267 | 0.90 | LSS (0.41) | GSK3BLSSBCHEACHEHRH1 | |
| Fumaric Acid SCHEMBL10591933 | 0.88 | LSS (0.41) | GSK3BLSSBCHEACHEHRH1 | |
| Fumaric Acid SCHEMBL9230988 | 0.88 | LSS (0.48) | LSSBCHEACHEHRH1KDM4E | |
| Maleic Acid SCHEMBL9230985 | 0.88 | LSS (0.48) | LSSBCHEACHEHRH1KDM4E | |
| Fumaric Acid SCHEMBL9237908 | 0.88 | ALDH1A1 (0.48) | GSK3BLSSBCHEACHEHRH1 | |
| Maleic Acid SCHEMBL9237900 | 0.88 | ALDH1A1 (0.48) | GSK3BLSSBCHEACHEHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0641564-A1 | OPTICALLY ACTIVE CONDENSED PYRAZOLE COMPOUND FOR USE IN TREATING THROMBOCYTOPENIA AND ERYTHROPENIA | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1995-03-08 | — | — | EP | disclosed |
| EP-0338087-A1 | FUSED PYRAZOLE COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND THEIR MEDICINAL USE | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1989-10-25 | — | — | EP | disclosed |