Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.62 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4229605 | 0.85 | NPC1 (0.65) | EPHX1NPC1RAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL11623816 | 0.83 | L3MBTL1 (0.74) | NAMPTEPHX1MAPTL3MBTL1NPC1 | |
| SCHEMBL28648060 | 0.78 | EPHX1 (0.68) | NAMPTEPHX1L3MBTL1NPC1RAB9A | |
| SCHEMBL126657 | 0.78 | NPC1 (0.82) | NPC1RAB9ASMN1; SMN2CYP1A2HPGD | |
| SCHEMBL28928584 | 0.78 | NPC1 (0.82) | NPC1RAB9ASMN1; SMN2CYP1A2HPGD | |
| SCHEMBL520877 | 0.78 | NPC1 (0.82) | NPC1RAB9ASMN1; SMN2CYP1A2HPGD | |
| SCHEMBL7443737 | 0.77 | NPC1 (0.66) | MAPTNPC1RAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL20379282 | 0.77 | NAMPT (1.00) | NAMPTEPHX1MAPT | |
| SCHEMBL123652 | 0.76 | NPC1 (0.79) | L3MBTL1NPC1RAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL13766441 | 0.76 | NPC1 (0.69) | MAPTNPC1RAB9ASMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0638553-A1 | Carboxylic acid amides having a terminal carboxylic acid group as aggregation inhibiting drugs | Dr. Karl Thomae GmbH (DE) | 1995-02-15 | — | — | EP | disclosed |