Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 7/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | AGXT | P21549 | 2/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9237638 | 0.83 | CXCR2 (0.44) | CXCR2LMNATDP1L3MBTL1KDM4E | |
| SCHEMBL198499 | 0.80 | CYP1A2 (0.55) | CXCR2LMNATSHRMEN1KMT2A | |
| SCHEMBL30454012 | 0.80 | CYP1A2 (0.55) | CXCR2LMNATSHRMEN1KMT2A | |
| SCHEMBL3365264 | 0.79 | MEN1 (0.60) | CXCR2KDM4EMAOBAPPELOVL1 | |
| SCHEMBL21503592 | 0.79 | MAOB (0.59) | CXCR2MAOBAPPELOVL1IDO1 | |
| SCHEMBL510047 | 0.79 | MAOB (0.49) | CXCR2KDM4EMAOBAPPELOVL1 | |
| SCHEMBL9239245 | 0.79 | MAOB (0.42) | CXCR2MAOBAPPNR4A2ELOVL1 | |
| Hydrochloric Acid SCHEMBL21491730 | 0.78 | MAOB (0.60) | CXCR2MAOBAPPELOVL1IDO1 | |
| SCHEMBL3416184 | 0.78 | CALM1 (0.50) | MAOBAPPIDO1AGXTRAB9A | |
| Hydrochloric Acid SCHEMBL30744406 | 0.78 | MAOB (0.60) | CXCR2MAOBAPPELOVL1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0665223-A1 | Antitumor agent, novel 3(2H)-pyridazinone derivatives and their preparation | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-08-02 | — | — | EP | disclosed |
| EP-0199281-B1 | PYRIDAZINONE DERIVATIVES, PREPARATION THEREOF, AND INSECTICIDAL, ACARICIDAL, NEMATICIDAL, FUNGICIDAL COMPOSITIONS | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1991-07-10 | — | — | EP | disclosed |
| US-4837217-A | Pyridazinone derivatives, preparation thereof, and insecticidal, acaricidal, nematicidal, fungicidal compositions | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 1989-06-06 | — | — | US | disclosed |
| EP-0199281-A2 | Pyridazinone derivatives, preparation thereof, and insecticidal, acaricidal, nematicidal, fungicidal compositions | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1986-10-29 | — | — | EP | disclosed |