Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 6/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9017564 | 0.77 | DHODH (0.61) | DHODHRAB9AKMT2APOLBNPC1 | |
| SCHEMBL9188142 | 0.76 | DHODH (0.70) | DHODHKMT2ATSHRKDM4ELMNA | |
| SCHEMBL15196662 | 0.75 | DHODH (0.62) | DHODHRAB9AKMT2APOLBNPC1 | |
| SCHEMBL25813258 | 0.73 | DHODH (0.74) | DHODHRAB9AKMT2ACYP1A2CYP2C9 | |
| SCHEMBL18118641 | 0.73 | DHODH (0.70) | DHODHRAB9AKMT2APOLBTSHR | |
| SCHEMBL16741993 | 0.73 | DHODH (0.70) | DHODHRAB9AKMT2APOLBTSHR | |
| SCHEMBL6655226 | 0.73 | DHODH (0.70) | DHODHRAB9AKMT2APOLBTSHR | |
| SCHEMBL5049041 | 0.73 | DHODH (0.70) | DHODHRAB9AKMT2APOLBTSHR | |
| SCHEMBL27242987 | 0.73 | DHODH (0.74) | DHODHRAB9AKMT2ACYP1A2CYP2C9 | |
| SCHEMBL9239066 | 0.73 | DHODH (0.59) | DHODHRAB9AKMT2APOLBCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0652214-A1 | N-Aryl-2-cyano-3-hydroxy propenamide derivatives, a method for their preparation, their use as medicaments and pharmaceutical compositions containing them | ROUSSEL UCLAF (FR) | 1995-05-10 | — | — | EP | disclosed |