Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 7/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 4/20 | 0.44 |
| ▸ | DRD3 | P35462 | 3/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9242599 | 0.99 | MTNR1A (0.46) | MTNR1AMTNR1BCYP1A2MAPTCYP2C9 | |
| Hydrochloric Acid SCHEMBL9241618 | 0.92 | MTNR1A (0.46) | MTNR1AMTNR1BCYP1A2MAPTCYP2C9 | |
| SCHEMBL9242382 | 0.87 | MTNR1A (0.48) | MTNR1AMTNR1BCYP1A2MAPTCYP2C9 | |
| Hydrochloric Acid SCHEMBL9243559 | 0.86 | MTNR1A (0.47) | MTNR1AMTNR1BCYP1A2MAPTCYP2C9 | |
| SCHEMBL9533770 | 0.84 | DRD2 (0.53) | MTNR1AMTNR1BCYP1A2MAPTCYP2C9 | |
| Hydrochloric Acid SCHEMBL9243922 | 0.83 | DRD2 (0.52) | MTNR1AMTNR1BCYP1A2MAPTCYP2C9 | |
| SCHEMBL9243895 | 0.81 | MTNR1A (0.53) | MTNR1AMTNR1BCYP1A2MAPTCYP2C9 | |
| Hydrochloric Acid SCHEMBL9241334 | 0.80 | MTNR1A (0.52) | MTNR1AMTNR1BCYP1A2MAPTCYP2C9 | |
| SCHEMBL9241255 | 0.80 | MTNR1A (0.49) | MTNR1AMTNR1BCYP1A2MAPTCYP2C9 | |
| SCHEMBL9239200 | 0.80 | MTNR1A (0.55) | MTNR1AMTNR1BCYP1A2MAPTCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5463105-A | Therapy for cardiovascular, nervous system disorders | BAYER AKTIENGESELLSCHAFT (DE) | 1995-10-31 | — | — | US | disclosed |
| US-5298513-A | Serotonin antagonist | BAYER AKTIENGESELLSCHAFT (DE) | 1994-03-29 | — | — | US | disclosed |
| EP-0270947-B1 | SUBSTITUTED BASIC 2-AMINOTETRALINES | BAYER AG (DE) | 1993-05-19 | — | — | EP | disclosed |
| US-5153225-A | For treating disorders of the central nervous system, cardiovascular system and intestinal tract | BAYER AKTIENGESELLSCHAFT (DE) | 1992-10-06 | — | — | US | disclosed |
| US-5026857-A | Cetnral nervous system disorders; antiserotonine agent | BAYER AKTIENGESELLSCHAFT (DE) | 1991-06-25 | — | — | US | disclosed |
| US-4880802-A | CENTRAL NERVOUS SYSTEM | BAYER AKTIENGESELLSCHAFT (DE) | 1989-11-14 | — | — | US | disclosed |
| EP-0270947-A2 | Substituted basic 2-aminotetralines | BAYER AG (DE) | 1988-06-15 | — | — | EP | disclosed |