Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.53 |
| ▸ | DRD3 | P35462 | 4/20 | 0.53 |
| ▸ | HTR1D | P28221 | 1/20 | 0.52 |
| ▸ | DRD4 | P21917 | 2/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9243922 | 0.99 | DRD2 (0.52) | DRD2DRD3HTR1DDRD4HTR1A | |
| SCHEMBL9239130 | 0.84 | MTNR1A (0.46) | DRD2DRD3HTR1DDRD4HTR1A | |
| Hydrochloric Acid SCHEMBL9242599 | 0.83 | MTNR1A (0.46) | DRD2DRD3HTR1DDRD4HTR1A | |
| SCHEMBL8969041 | 0.82 | CHRM2 (0.51) | DRD2DRD3DRD4HTR1AADRA1D | |
| SCHEMBL9239204 | 0.80 | DRD2 (0.65) | DRD2DRD3DRD4MTNR1AMTNR1B | |
| Hydrochloric Acid SCHEMBL9242418 | 0.79 | DRD2 (0.63) | DRD2DRD3DRD4MTNR1AMTNR1B | |
| SCHEMBL8894131 | 0.77 | DRD2 (0.83) | DRD2DRD3HTR1DDRD4MTNR1A | |
| Hydrochloric Acid SCHEMBL9241618 | 0.76 | MTNR1A (0.46) | HTR1AMTNR1AMTNR1BCYP1A2MAPT | |
| SCHEMBL8970546 | 0.75 | DRD2 (0.43) | DRD2DRD3DRD4HTR1AADRA1D | |
| SCHEMBL9534218 | 0.75 | MTNR1A (0.52) | DRD2DRD3DRD4HTR1AADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5153225-A | For treating disorders of the central nervous system, cardiovascular system and intestinal tract | BAYER AKTIENGESELLSCHAFT (DE) | 1992-10-06 | — | — | US | claimed |
| EP-0270947-B1 | SUBSTITUTED BASIC 2-AMINOTETRALINES | BAYER AG (DE) | 1993-05-19 | — | — | EP | disclosed |
| EP-0270947-A2 | Substituted basic 2-aminotetralines | BAYER AG (DE) | 1988-06-15 | — | — | EP | disclosed |