Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | GALR3 | O60755 | 1/20 | 0.44 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.44 |
| ▸ | GPR183 | P32249 | 1/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | VNN1 | O95497 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10933551 | 0.92 | ATM (0.50) | SMN1; SMN2KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL9239206 | 0.91 | MAPK14 (0.44) | SMN1; SMN2KMT2ANPC1RAB9ATSHR | |
| SCHEMBL9240302 | 0.90 | SMN1; SMN2 (0.47) | SMN1; SMN2KMT2ANPC1RAB9ATSHR | |
| SCHEMBL9288437 | 0.89 | RXRA (0.50) | SMN1; SMN2KMT2ANPC1RAB9ALMNA | |
| SCHEMBL14768984 | 0.89 | MAOB (0.46) | SMN1; SMN2KMT2ANPC1RAB9ATSHR | |
| SCHEMBL18672266 | 0.88 | SMN1; SMN2 (0.53) | SMN1; SMN2KMT2ANPC1RAB9ATSHR | |
| SCHEMBL14760814 | 0.87 | RAB9A (0.46) | SMN1; SMN2KMT2ANPC1RAB9ATSHR | |
| SCHEMBL9237101 | 0.86 | SMN1; SMN2 (0.43) | SMN1; SMN2KMT2ANPC1RAB9ATSHR | |
| SCHEMBL14760853 | 0.85 | SMN1; SMN2 (0.48) | SMN1; SMN2KMT2ANPC1RAB9ATSHR | |
| SCHEMBL10725634 | 0.84 | SMN1; SMN2 (0.44) | SMN1; SMN2KMT2ANPC1RAB9ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0665223-A1 | Antitumor agent, novel 3(2H)-pyridazinone derivatives and their preparation | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-08-02 | — | — | EP | disclosed |