Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.45 |
| ▸ | HRH1 known ✓ | P35367 | 8/20 | 0.42 |
| ▸ | HTR2A known ✓ | P28223 | 4/20 | 0.42 |
| ▸ | HTR2C known ✓ | P28335 | 3/20 | 0.42 |
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.42 |
| ▸ | DRD2 known ✓ | P14416 | 2/20 | 0.42 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.42 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.42 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.42 |
| ▸ | DRD1 known ✓ | P21728 | 1/20 | 0.42 |
| ▸ | HTR2B known ✓ | P41595 | 2/20 | 0.37 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.37 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.37 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6991281 | 0.92 | HRH1 (0.43) | HRH1HTR2AHTR2CCHRM2CHRM1 | |
| Fumaric Acid SCHEMBL9239338 | 0.91 | MAPK1 (0.44) | MAPK1MEN1MAPTKMT2AHRH1 | |
| Fumaric Acid SCHEMBL9240592 | 0.88 | MAPK1 (0.41) | MAPK1MEN1MAPTKMT2AHRH1 | |
| Fumaric Acid SCHEMBL9386969 | 0.86 | MAPK1 (0.43) | MAPK1MEN1MAPTKMT2AHRH1 | |
| Fumaric Acid SCHEMBL9386964 | 0.86 | MAPK1 (0.43) | MAPK1MEN1MAPTKMT2AHRH1 | |
| Fumaric Acid SCHEMBL9385079 | 0.85 | MAPK1 (0.39) | MAPK1MEN1MAPTKMT2AHRH1 | |
| Fumaric Acid SCHEMBL9385069 | 0.85 | MAPK1 (0.39) | MAPK1MEN1MAPTKMT2AHRH1 | |
| Water SCHEMBL9129109 | 0.83 | HRH1 (0.38) | MAPK1MEN1MAPTKMT2AHRH1 | |
| Water SCHEMBL6988465 | 0.83 | HRH1 (0.38) | MAPK1MEN1MAPTKMT2AHRH1 | |
| Fumaric Acid SCHEMBL9386205 | 0.82 | DRD3 (0.37) | MAPK1MEN1MAPTKMT2AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5468743-A | Imidazo[2,1-b]benzazepine derivatives, compositions and method of use | JANSSEN PHARMACEUTICA N.V. (BE) | 1995-11-21 | — | — | US | disclosed |
| EP-0588858-A1 | IMIDAZO 2,1-b] 3]BENZAZEPINE DERIVATIVES, COMPOSITIONS AND METHOD OF USE | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-03-30 | — | — | EP | disclosed |
| WO-1992022551-A1 | IMIDAZO[2,1-b][3]BENZAZEPINE DERIVATIVES, COMPOSITIONS AND METHOD OF USE | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-12-23 | — | — | WO | disclosed |