Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 1/20 | 0.52 |
| ▸ | CTSD | P07339 | 1/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9461499 | 0.79 | ALOX5 (0.63) | KDM4EALDH1A1SMN1; SMN2EPHX1TP53 | |
| SCHEMBL7789976 | 0.79 | MDM2 (0.75) | MDM2TAAR1RAB9AKMT2AMEN1 | |
| SCHEMBL27802114 | 0.77 | CTSD (0.56) | MDM2CTSDTAAR1KMT2AMEN1 | |
| SCHEMBL9004626 | 0.75 | CTSD (0.54) | MDM2CTSDTAAR1KMT2AMEN1 | |
| SCHEMBL9121193 | 0.74 | ALDH1A1 (0.73) | KDM4EL3MBTL1ALDH1A1PKMSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL28030454 | 0.73 | CTSD (0.52) | MDM2CTSDTAAR1KMT2AMEN1 | |
| SCHEMBL3505987 | 0.71 | — | — | |
| SCHEMBL10758878 | 0.71 | MDM2 (0.55) | MDM2TAAR1RAB9AKMT2AMEN1 | |
| SCHEMBL27658590 | 0.71 | CYP17A1 (0.50) | MDM2CTSDRAB9AKMT2AMEN1 | |
| Bicarbonate SCHEMBL23093808 | 0.70 | MDM2 (0.54) | MDM2CTSDTAAR1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5436252-A | Antiischemic agents, stroke, Alzheimer's or Parkinson's diseases | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-07-25 | — | — | US | disclosed |
| EP-0273310-B1 | 5-Aryl-3H-1,2,4-triazol-3-ones and their use as anticonvulsants | MERRELL DOW PHARMA (US) | 1995-06-21 | — | — | EP | disclosed |
| EP-0273309-B1 | 5-Aryl-3H-1,2,4-triazol-3-ones and their use in the treatment of neurodegenerative disorders | MERRELL DOW PHARMA (US) | 1995-01-11 | — | — | EP | disclosed |
| EP-0273310-A2 | 5-Aryl-3H-1,2,4-triazol-3-ones and their use as anticonvulsants | MERRELL PHARMACEUTICALS INC. (US) | 1988-07-06 | — | — | EP | disclosed |
| EP-0273309-A2 | 5-Aryl-3H-1,2,4-triazol-3-ones and their use in the treatment of neurodegenerative disorders | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-07-06 | — | — | EP | disclosed |