SCHEMBL9246331

SCHEMBL9246331

O=C(O)c1nc2ccccc2cc1C1=NCCN1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NISCH Q9Y2I1 14/20 0.54
KDM4E B2RXH2 5/20 0.50
ALDH1A1 P00352 4/20 0.50
CYP1A2 P05177 4/20 0.50
CYP2D6 P10635 2/20 0.50
CYP3A4 P08684 1/20 0.50
ALOX15 P16050 1/20 0.50
LMNA P02545 1/20 0.49
PMP22 Q01453 1/20 0.49
MEN1 O00255 1/20 0.46
KMT2A Q03164 1/20 0.46
MAPT P10636 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
ADRA2A P08913 1/20 0.42
HPGD P15428 1/20 0.42
ADRA2B P18089 1/20 0.42
ADRA2C P18825 1/20 0.42
MAOA P21397 1/20 0.42
MAOB P27338 1/20 0.42
HSD17B10 Q99714 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9065016 0.78 TSHR (0.52) NISCHKDM4EALDH1A1CYP1A2CYP2D6
SCHEMBL6824337 0.78 NISCH (0.56) NISCHKDM4EALDH1A1CYP1A2CYP2D6
SCHEMBL8376962 0.77 ALDH1A1 (0.45) KDM4EALDH1A1MEN1KMT2AMAPT
SCHEMBL2001891 0.75 ALDH1A1 (0.57) KDM4EALDH1A1LMNAMEN1KMT2A
SCHEMBL3399983 0.73 NISCH (0.66) NISCHKDM4EALDH1A1CYP1A2CYP2D6
SCHEMBL9195272 0.73 NISCH (0.53) NISCHKDM4EALDH1A1CYP1A2CYP3A4
SCHEMBL1526540 0.72 NISCH (0.60) NISCH
SCHEMBL11089095 0.71 KDM4E (0.50) KDM4EALDH1A1CYP3A4MEN1KMT2A
Pyridine SCHEMBL2285312 0.71 ALDH1A1 (0.50) KDM4EALDH1A1LMNAMEN1KMT2A
SCHEMBL31556386 0.71 KDM4E (0.50) KDM4EALDH1A1CYP3A4MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5478795-A Selective postemergence control of undesirable plant species in the presence of crops AMERICAN CYANAMID COMPANY (US) 1995-12-26 US disclosed
US-5030271-A Isopropylammonium 2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)nicotinate and 5-ethyl-2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)nicotinic acid AMERICAN CYANAMID COMPANY (US) 1991-07-09 US disclosed