Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11189207 | 0.80 | ALDH1A1 (0.55) | ALDH1A1MAPTL3MBTL1NPSR1TSHR | |
| SCHEMBL7164182 | 0.78 | ALDH1A1 (0.52) | ALDH1A1MAPTL3MBTL1TSHRMEN1 | |
| SCHEMBL7160534 | 0.75 | ALDH1A1 (0.53) | ALDH1A1MAPTNPSR1MEN1KMT2A | |
| SCHEMBL7204676 | 0.74 | ALDH1A1 (0.77) | ALDH1A1MAPTL3MBTL1TSHRKDM4E | |
| SCHEMBL11650278 | 0.74 | ALDH1A1 (0.58) | ALDH1A1MAPTNPSR1TSHRKMT2A | |
| SCHEMBL11689596 | 0.74 | ALDH1A1 (0.58) | ALDH1A1MAPTNPSR1TSHRKMT2A | |
| SCHEMBL197477 | 0.71 | ALDH1A1 (0.54) | ALDH1A1MAPTNPSR1TSHRKDM4E | |
| SCHEMBL9400292 | 0.71 | ALDH1A1 (0.70) | ALDH1A1MAPTL3MBTL1MEN1KMT2A | |
| SCHEMBL27887014 | 0.70 | ALDH1A1 (0.40) | ALDH1A1MAPTL3MBTL1TSHRHPGD | |
| SCHEMBL11172356 | 0.70 | ALDH1A1 (0.52) | ALDH1A1MAPTL3MBTL1NPSR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5446194-A | Pharmacologically active catechol derivatives | ORION-YHTYMA OY (FI) | 1995-08-29 | — | — | US | disclosed |
| US-5283352-A | Transferase inhibitor | ORION-YHTYMA OY (FI) | 1994-02-01 | — | — | US | disclosed |
| US-5112861-A | Inhibitors of catechol-methyl-transferase enzyme, levodopa | ORION-YHTYMA OY (FI) | 1992-05-12 | — | — | US | disclosed |
| US-4963590-A | ENZYME INHIBITOR FOR TREATING PARKINSON'S DISEASE ALONG WITH DOPA;POTENTIATION | ORION-YHTYMA OY (FI) | 1990-10-16 | — | — | US | disclosed |