Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 5/20 | 0.69 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.69 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.64 |
| ▸ | CHRM3 | P20309 | 7/20 | 0.59 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.59 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.55 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 1/20 | 0.55 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.55 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.55 |
| ▸ | MAOA | P21397 | 1/20 | 0.55 |
| ▸ | DRD4 | P21917 | 1/20 | 0.55 |
| ▸ | MAOB | P27338 | 1/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.55 |
| ▸ | HRH1 | P35367 | 1/20 | 0.55 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.55 |
| ▸ | DRD3 | P35462 | 1/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL924276 | 0.89 | OPRM1 (0.77) | OPRM1SIGMAR1OPRD1CHRM3CHRM2 | |
| SCHEMBL15920013 | 0.86 | OPRM1 (0.80) | OPRM1SIGMAR1OPRD1CHRM3CHRM2 | |
| SCHEMBL926325 | 0.86 | OPRM1 (0.69) | OPRM1SIGMAR1OPRD1CHRM3CHRM2 | |
| SCHEMBL1173407 | 0.84 | OPRM1 (0.56) | OPRM1SIGMAR1OPRD1CHRM3SLC22A1 | |
| SCHEMBL1172872 | 0.83 | OPRM1 (0.58) | OPRM1SIGMAR1OPRD1CHRM3SLC22A1 | |
| SCHEMBL925917 | 0.83 | OPRM1 (0.86) | OPRM1SIGMAR1OPRD1CHRM3CHRM2 | |
| SCHEMBL6045571 | 0.83 | OPRM1 (1.00) | OPRM1SIGMAR1OPRD1CHRM3CHRM2 | |
| SCHEMBL1172750 | 0.82 | OPRM1 (0.56) | OPRM1SIGMAR1OPRD1CHRM3SLC22A1 | |
| SCHEMBL8569723 | 0.82 | CHRM2 (0.70) | OPRM1SIGMAR1OPRD1CHRM3CHRM2 | |
| Hydrochloric Acid SCHEMBL29651340 | 0.81 | OPRM1 (0.97) | OPRM1SIGMAR1OPRD1CHRM3CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110046180-A1 | N-ARYL-N-PIPERIDIN-4-YL-PROPIONAMIDE DERIVATIVES AND THEIR USE AS OPIOID RECEPTOR LIGANDS | NEUROSEARCH A/S (DK) | 2011-02-24 | — | — | US | disclosed |
| US-20110046180-A1 | N-ARYL-N-PIPERIDIN-4-YL-PROPIONAMIDE DERIVATIVES AND THEIR USE AS OPIOID RECEPTOR LIGANDS | NEUROSEARCH A/S (DK) | 2011-02-24 | — | — | US | disclosed |
| US-20110046180-A1 | N-ARYL-N-PIPERIDIN-4-YL-PROPIONAMIDE DERIVATIVES AND THEIR USE AS OPIOID RECEPTOR LIGANDS | NEUROSEARCH A/S (DK) | 2011-02-24 | — | — | US | disclosed |
| US-20110009449-A1 | N-ARYL-N-PIPERIDIN-4-YL-PROPIONAMIDE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | NEUROSEARCH A/S (DK) | 2011-01-13 | — | — | US | disclosed |
| US-20110009449-A1 | N-ARYL-N-PIPERIDIN-4-YL-PROPIONAMIDE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | NEUROSEARCH A/S (DK) | 2011-01-13 | — | — | US | disclosed |
| US-20110009449-A1 | N-ARYL-N-PIPERIDIN-4-YL-PROPIONAMIDE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | NEUROSEARCH A/S (DK) | 2011-01-13 | — | — | US | disclosed |
| WO-2009077585-A1 | N-ARYL-N-PIPERIDIN-4-YL-PROPIONAMIDE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | NEUROSEARCH A/S (DK) | 2009-06-25 | — | — | WO | disclosed |
| WO-2009077584-A1 | N-ARYL-N-PIPERIDIN-4-YL-PROPIONAMIDE DERIVATIVES AND THEIR USE AS OPIOID RECEPTOR LIGANDS | NEUROSEARCH A/S (DK) | 2009-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046180-A1 | N-ARYL-N-PIPERIDIN-4-YL-PROPIONAMIDE DERIVATIVES AND THEIR USE AS OPIOID RECEPTOR LIGANDS | OPRL1, OPRD1, OPRK1 | OPRM1 4/4885SIGMAR1 26/4885OPRD1 2/4885 |
| US-20110009449-A1 | N-ARYL-N-PIPERIDIN-4-YL-PROPIONAMIDE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | SLC18A2, SLC6A2, OPRL1 | OPRM1 24/4885SIGMAR1 62/4885OPRD1 21/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.