Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.33 |
| ▸ | PYGL | P06737 | 2/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ASPH | Q12797 | 1/20 | 0.32 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.32 |
| ▸ | ACLY | P53396 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9247951 | 0.89 | KEAP1 (0.41) | KEAP1NFE2L2CYP3A4KDM4AKDM5A | |
| SCHEMBL9246039 | 0.76 | KEAP1 (0.37) | KEAP1NFE2L2KDM4EASPHKDM8 | |
| SCHEMBL8974977 | 0.74 | KEAP1 (0.53) | KEAP1NFE2L2CYP3A4KDM4AKDM5A | |
| SCHEMBL5461009 | 0.71 | KEAP1 (0.43) | KEAP1NFE2L2CYP3A4KDM4AKDM5A | |
| SCHEMBL2195554 | 0.70 | CYP1A2 (0.44) | CYP3A4POLBAPEX1KDM4EALDH1A1 | |
| SCHEMBL10539386 | 0.69 | KEAP1 (0.48) | KEAP1NFE2L2CYP3A4POLBAPEX1 | |
| SCHEMBL7596205 | 0.69 | KEAP1 (0.48) | KEAP1NFE2L2CYP3A4KDM4AKDM5A | |
| SCHEMBL7041352 | 0.69 | CYP3A4 (0.50) | KEAP1NFE2L2CYP3A4KDM4AKDM5A | |
| SCHEMBL8038276 | 0.69 | KEAP1 (0.48) | KEAP1NFE2L2CYP3A4KDM4AKDM5A | |
| SCHEMBL20045612 | 0.69 | CYP3A4 (0.50) | KEAP1NFE2L2CYP3A4POLBAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0355774-B1 | Nucleus-fluorinated aromatic carboxylates and processes for their production | ASAHI GLASS CO LTD (JP) | 1995-04-26 | — | — | EP | disclosed |
| US-4985588-A | Nucleus-fluorinated aromatic carboxylates and processes for their production | ASAHI GLASS COMPANY LTD. (JP) | 1991-01-15 | — | — | US | disclosed |