Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.34 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
| ▸ | RARB | P10826 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4506073 | 0.84 | KEAP1 (0.39) | KEAP1NFE2L2RARBKDM4EGABRP | |
| SCHEMBL9723102 | 0.83 | CYP3A4 (0.46) | KEAP1NFE2L2MRGPRX4KDM4EALDH1A1 | |
| SCHEMBL8578094 | 0.80 | GABRP (0.40) | KEAP1NFE2L2RARBKDM4EGABRP | |
| SCHEMBL22972614 | 0.77 | KEAP1 (0.52) | KEAP1NFE2L2KDM4AKDM5AKDM4C | |
| SCHEMBL2477663 | 0.77 | KEAP1 (0.41) | KEAP1NFE2L2MRGPRX4KDM4AKDM5A | |
| SCHEMBL3337887 | 0.74 | ALDH1A1 (0.41) | KEAP1NFE2L2MRGPRX4RARBKDM4E | |
| SCHEMBL29376622 | 0.74 | KEAP1 (0.52) | KEAP1NFE2L2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL2434231 | 0.74 | KEAP1 (0.52) | KEAP1NFE2L2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1541651 | 0.73 | CES2 (0.41) | RARBKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL26497713 | 0.73 | KEAP1 (0.47) | KEAP1NFE2L2KDM4EALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070021634-A1 | SYNTHESIS OF THERAPEUTIC DIPHENYL ETHERS | PFIZER INC | 2007-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070021634-A1 | SYNTHESIS OF THERAPEUTIC DIPHENYL ETHERS | DHFR, CYP2F1, EPOR | KEAP1 1129/4885NFE2L2 543/4885MRGPRX4 1434/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.