SCHEMBL9249667

SCHEMBL9249667

CC(C)(C)OC(=O)CC(O)(CC(=O)OC(C)(C)C)C(=O)O

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.48
TSHR P16473 3/20 0.38
HMGCR P04035 1/20 0.37
CHRM1 P11229 1/20 0.37
TBXA2R P21731 1/20 0.37
ADRA1A P35348 1/20 0.37
CYP2D6 P10635 2/20 0.36
CYP2C19 P33261 1/20 0.36
HIF1A Q16665 1/20 0.36
TET2 Q6N021 1/20 0.34
DGAT1 O75907 1/20 0.32
SLC13A5 Q86YT5 2/20 0.32
HDAC3 O15379 1/20 0.32
HDAC1 Q13547 1/20 0.32
HDAC2 Q92769 1/20 0.32
HDAC8 Q9BY41 1/20 0.32
HDAC6 Q9UBN7 1/20 0.32
MEN1 O00255 1/20 0.32
GAA P10253 1/20 0.32
KMT2A Q03164 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2829360 0.94 ALDH1A1 (0.60) ALDH1A1TSHRHMGCRCHRM1TBXA2R
SCHEMBL17243716 0.92 ALDH1A1 (0.41) ALDH1A1TSHRHMGCRCHRM1TBXA2R
SCHEMBL2957592 0.89 ALDH1A1 (0.39) ALDH1A1TSHRHMGCRCHRM1TBXA2R
SCHEMBL2829358 0.82 DGAT1 (0.41) HMGCRCHRM1TBXA2RADRA1ACYP2D6
SCHEMBL9249653 0.79 ALDH1A1 (0.41) ALDH1A1TSHRHMGCRCHRM1TBXA2R
SCHEMBL31675017 0.79 ALDH1A1 (0.52) ALDH1A1TSHRHMGCRCHRM1TBXA2R
SCHEMBL4831111 0.79 CYP2D6 (0.37) ALDH1A1TSHRHMGCRCHRM1TBXA2R
SCHEMBL6761013 0.79 CYP2D6 (0.37) ALDH1A1TSHRHMGCRCHRM1TBXA2R
SCHEMBL27568297 0.78 TSHR (0.35) ALDH1A1TSHRHMGCRCHRM1TBXA2R
SCHEMBL10939959 0.78 HMGCR (0.48) ALDH1A1TSHRHMGCRCHRM1TBXA2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018065475-A1 METHOD FOR THE PRODUCTION OF METHYLSUCCINIC ACID AND THE ANHYDRIDE THEREOF FROM CITRIC ACID KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2018-04-12 WO disclosed
US-20110124765-A1 Versatile Biodegradable Elastic Polymers Featured with Dual Crosslinking Mechanism for Biomedical Applications BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2011-05-26 US disclosed
US-5391771-A Reacting citric acid or esters on hydrogenation catalyst in nonaqueous solvent BASF AKTIENGESELLSCHAFT 1995-02-21 US disclosed