Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.51 |
| ▸ | DRD4 | P21917 | 2/20 | 0.51 |
| ▸ | HTR2A | P28223 | 2/20 | 0.51 |
| ▸ | HTR2C | P28335 | 2/20 | 0.51 |
| ▸ | HTR2B | P41595 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.48 |
| ▸ | DGKA | P23743 | 2/20 | 0.48 |
| ▸ | DGKG | P49619 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | GMNN | O75496 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | BLM | P54132 | 2/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9253356 | 0.91 | HIF1A (0.46) | DRD2DRD4HTR2AHTR2CHTR2B | |
| SCHEMBL9379143 | 0.85 | MAPT (0.49) | DRD2DRD4HTR2AHTR2CHTR2B | |
| SCHEMBL9632595 | 0.84 | MAPT (0.48) | DRD2DRD4HTR2AHTR2CHTR2B | |
| SCHEMBL9246640 | 0.83 | SETD7 (0.61) | DRD2DRD4HTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL9632502 | 0.83 | MAPT (0.47) | DRD2DRD4HTR2AHTR2CHTR2B | |
| SCHEMBL22558411 | 0.80 | MAPT (0.46) | DRD2DRD4HTR2AHTR2CHTR2B | |
| SCHEMBL10566280 | 0.80 | CARM1 (0.48) | DRD2DRD4HTR2AHTR2CHTR2B | |
| SCHEMBL19436970 | 0.80 | DRD2 (0.47) | DRD2DRD4HTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL9630458 | 0.78 | PSMB1 (0.46) | DRD2DRD4HTR2AHTR2CHTR2B | |
| SCHEMBL24604543 | 0.77 | MAPT (0.43) | DRD2DRD4HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5470851-A | Antihistamine, anticoagulants | SANKYO COMPANY, LIMITED (JP) | 1995-11-28 | — | — | US | disclosed |
| EP-0463873-A1 | Thiazolidinecarboxylic acid amide derivatives having anti-allergic activity, their preparation and their use | Sankyo Company Limited (JP) | 1992-01-02 | — | — | EP | disclosed |
| US-4835157-A | Thieno- and furopyrimidine-2,4-dione piperidine derivatives as serotonin antagonists and alpha adrenergic blocking agents | ORTHO PHARMACEUTICAL CORPORATION (US) | 1989-05-30 | — | — | US | disclosed |