Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 13/20 | 0.59 |
| ▸ | RXRB | P28702 | 10/20 | 0.59 |
| ▸ | RXRG | P48443 | 8/20 | 0.59 |
| ▸ | CYP26A1 | O43174 | 5/20 | 0.53 |
| ▸ | CYP26B1 | Q9NR63 | 4/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.53 |
| ▸ | RARB | P10826 | 6/20 | 0.51 |
| ▸ | RARG | P13631 | 6/20 | 0.51 |
| ▸ | RARA | P10276 | 5/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9175151 | 0.83 | RXRA (0.74) | RXRARXRBRXRGCYP26A1CYP26B1 | |
| SCHEMBL727936 | 0.80 | RXRA (0.74) | RXRARXRBRXRGCYP26A1CYP26B1 | |
| SCHEMBL9594812 | 0.79 | RXRA (0.56) | RXRARXRBRXRGCYP26A1CYP26B1 | |
| SCHEMBL8557337 | 0.78 | RARB (0.73) | RXRARXRBRXRGCYP26A1CYP26B1 | |
| SCHEMBL9165893 | 0.78 | RXRA (0.69) | RXRARXRBRXRGCYP26A1CYP26B1 | |
| SCHEMBL9175054 | 0.77 | RXRA (0.60) | RXRARXRBRXRGCYP26A1CYP26B1 | |
| SCHEMBL9595211 | 0.75 | RARB (0.60) | RXRARXRBRXRGCYP26A1CYP26B1 | |
| SCHEMBL6890738 | 0.75 | RXRA (0.78) | RXRARXRBRXRGCYP26A1CYP26B1 | |
| SCHEMBL7720657 | 0.74 | RXRA (1.00) | RXRARXRBRXRGCYP26A1CYP26B1 | |
| SCHEMBL7028435 | 0.74 | RXRA (0.56) | RXRARXRBRXRGCYP26A1CYP26B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0642499-A1 | RETINOIDS AND THEIR USE IN TREATING SKIN DISEASES AND LEUKEMIA | PFIZER INC. (US) | 1995-03-15 | — | — | EP | disclosed |
| WO-1993006086-A1 | RETINOIDS AND THEIR USE IN TREATING SKIN DISEASES AND LEUKEMIA | PFIZER INC. (US) | 1993-04-01 | — | — | WO | disclosed |