Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 8/20 | 0.73 |
| ▸ | RARA | P10276 | 7/20 | 0.73 |
| ▸ | RARG | P13631 | 7/20 | 0.73 |
| ▸ | CYP26A1 | O43174 | 4/20 | 0.73 |
| ▸ | MEN1 | O00255 | 2/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.73 |
| ▸ | PGR | P06401 | 1/20 | 0.73 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.73 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.73 |
| ▸ | BLVRB | P30043 | 1/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.59 |
| ▸ | RXRA | P19793 | 13/20 | 0.58 |
| ▸ | RXRB | P28702 | 10/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8552419 | 0.92 | RARA (0.71) | RARBRARARARGCYP26A1MEN1 | |
| SCHEMBL9118094 | 0.88 | RARA (0.59) | RARBRARARARGCYP26A1MEN1 | |
| SCHEMBL9120996 | 0.85 | RARA (0.61) | RARBRARARARGCYP26A1MEN1 | |
| Tamibarotene SCHEMBL36207 | 0.84 | RARB (1.00) | RARBRARARARGCYP26A1MEN1 | |
| Tamibarotene SCHEMBL29373818 | 0.84 | RARB (1.00) | RARBRARARARGCYP26A1MEN1 | |
| SCHEMBL9121356 | 0.84 | RARA (0.71) | RARBRARARARGCYP26A1MEN1 | |
| Tamibarotene SCHEMBL21055743 | 0.83 | RARB (0.97) | RARBRARARARGCYP26A1MEN1 | |
| SCHEMBL22845650 | 0.82 | RARB (0.61) | RARBRARARARGCYP26A1MEN1 | |
| SCHEMBL727936 | 0.80 | RXRA (0.74) | RARBRARARARGCYP26A1MEN1 | |
| SCHEMBL9117662 | 0.80 | RARB (0.68) | RARBRARARARGCYP26A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0619116-A2 | Use of synthetic retinoids for osteopathy | HOECHST JAPAN LIMITED (JP) | 1994-10-12 | — | — | EP | claimed |
| EP-0617020-A1 | Carboxylic acid derivatives having retinoic acid-like activity | Shudo, Koichi, Prof. Dr. (JP) | 1994-09-28 | — | — | EP | claimed |
| US-5767146-A | Anti-osteopathic composition | HOECHST JAPAN LIMITED (JP) | 1998-06-16 | — | — | US | disclosed |
| US-5716995-A | TREATING OR PREVENTING BONE DISEASES BY ADMINISTERING PHENOLIC, HETERO- OR NAPHTHYL- DERIVATIVES OF 1-HYDROXY-3-OXO-1-PROPENYL BENZOIC ACID TO PROMOTE OSTEOGENESIS | HOECHST JAPAN LIMITED (JP) | 1998-02-10 | — | — | US | disclosed |
| US-5703128-A | TREATING OSTEOPOROSIS, BONE FRACTURES | HOECHST JAPAN LIMITED (JP) | 1997-12-30 | — | — | US | disclosed |
| US-5525618-A | ENHANCING OSTEOGENESIS, PREVENTING OSTEOPOROSIS | HOECHST JAPAN LIMITED (JP) | 1996-06-11 | — | — | US | disclosed |
| US-5420145-A | Antileukemia | Shudo, Koichi (JP) | 1995-05-30 | — | — | US | disclosed |
| EP-0619116-A2 | Use of synthetic retinoids for osteopathy | HOECHST JAPAN LIMITED (JP) | 1994-10-12 | — | — | EP | disclosed |
| EP-0617020-A1 | Carboxylic acid derivatives having retinoic acid-like activity | Shudo, Koichi, Prof. Dr. (JP) | 1994-09-28 | — | — | EP | disclosed |