Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HRH1 | P35367 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16058363 | 0.81 | APOBEC3G (0.40) | GBA1TDP1ALDH1A1SRCLMNA | |
| SCHEMBL9261235 | 0.78 | HTR2A (0.46) | GBA1HTR2AHRH1TSHRTDP1 | |
| SCHEMBL5555050 | 0.76 | SRC (0.39) | TSHRTDP1ALDH1A1KDM4ESRC | |
| SCHEMBL4130950 | 0.75 | SRC (0.41) | TSHRALDH1A1SRCLMNA | |
| SCHEMBL438263 | 0.73 | SRC (0.40) | TSHRALDH1A1SRCLMNA | |
| SCHEMBL9021021 | 0.72 | GBA1 (0.38) | GBA1HTR2AHRH1TSHRTDP1 | |
| SCHEMBL5555043 | 0.71 | SRC (0.39) | TSHRALDH1A1SRCLMNA | |
| SCHEMBL3633092 | 0.71 | ALDH1A1 (0.42) | TSHRTDP1ALDH1A1SRCLMNA | |
| SCHEMBL9006009 | 0.71 | CA1 (0.42) | HTR2AALDH1A1SRC | |
| SCHEMBL669211 | 0.71 | SRC (0.54) | TSHRTDP1ALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995009158-A1 | TRICYCLIC DERIVATIVES | ZENECA LIMITED (GB) | 1995-04-06 | — | — | WO | disclosed |
| WO-1994007869-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1994-04-14 | — | — | WO | disclosed |