Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT2B | Q92831 | 1/20 | 0.47 |
| ▸ | HCAR3 | P49019 | 7/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MERTK | Q12866 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 3/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9251806 | 0.89 | HCAR3 (0.60) | KAT2BHCAR3MAPT | |
| SCHEMBL9248817 | 0.86 | LMNA (0.55) | KAT2BHCAR3LMNAMAPTKMT2A | |
| SCHEMBL9253843 | 0.80 | HCAR3 (0.47) | KAT2BHCAR3LMNAMAPTKMT2A | |
| SCHEMBL9254715 | 0.78 | HCAR3 (0.45) | KAT2BHCAR3LMNAMAPTKMT2A | |
| SCHEMBL1602521 | 0.76 | HCAR3 (0.76) | HCAR3LMNAMAPTKMT2APKM | |
| SCHEMBL24993978 | 0.75 | KAT2B (0.63) | KAT2BHCAR3LMNAMERTKMAPT | |
| SCHEMBL401028 | 0.75 | HCAR3 (0.67) | HCAR3MAPTKMT2APKMALDH1A1 | |
| SCHEMBL289572 | 0.71 | VCAM1 (0.61) | LMNAMAPTALDH1A1VCAM1 | |
| SCHEMBL506550 | 0.71 | HCAR3 (0.74) | HCAR3LMNAMAPTKMT2AALDH1A1 | |
| SCHEMBL9251020 | 0.71 | HCAR3 (0.47) | HCAR3MERTKMAPTKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5434150-A | Anticoagulants, cardiovascular disorders | DR. KARL THOMAE GMBH (DE) | 1995-07-18 | — | — | US | disclosed |
| EP-0531883-A1 | Condensed 5-membered ring heterocycles, process for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1993-03-17 | — | — | EP | disclosed |