Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | F2 | P00734 | 6/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | GCG | P01275 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9248587 | 0.91 | HDAC6 (0.43) | HDAC6HDAC1HDAC8HDAC3HDAC2 | |
| SCHEMBL9249002 | 0.87 | ITGB3 (0.50) | HDAC6HDAC1HDAC8ITGB3ITGA2B | |
| SCHEMBL9256145 | 0.85 | F2 (0.49) | ITGB3ITGA2BF2 | |
| SCHEMBL9248855 | 0.84 | ITGB3 (0.47) | HDAC6HDAC1HDAC8ITGB3ITGA2B | |
| SCHEMBL9249490 | 0.84 | HDAC1 (0.56) | HDAC6HDAC1HDAC8ITGB3ITGA2B | |
| SCHEMBL9254163 | 0.83 | KDM4E (0.41) | HDAC6HDAC1HDAC8HDAC3HDAC2 | |
| SCHEMBL9257024 | 0.81 | KDM4E (0.41) | HDAC6HDAC1HDAC8ITGB3ITGA2B | |
| SCHEMBL9255028 | 0.80 | ITGB3 (0.47) | HDAC6HDAC1HDAC8ITGB3ITGA2B | |
| SCHEMBL9254680 | 0.79 | HPGD (0.45) | HDAC6HDAC1HDAC8ITGB3ITGA2B | |
| SCHEMBL9245467 | 0.78 | HDAC1 (0.38) | HDAC6HDAC1HDAC8HDAC3HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5434150-A | Anticoagulants, cardiovascular disorders | DR. KARL THOMAE GMBH (DE) | 1995-07-18 | — | — | US | disclosed |
| EP-0531883-A1 | Condensed 5-membered ring heterocycles, process for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1993-03-17 | — | — | EP | disclosed |