Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9251757 | 0.92 | HPGD (0.44) | HPGDTP53HDAC6HDAC1HDAC8 | |
| SCHEMBL9251368 | 0.79 | HDAC6 (0.45) | TP53HDAC6HDAC1HDAC8ATM | |
| SCHEMBL9249002 | 0.77 | ITGB3 (0.50) | HDAC6HDAC1HDAC8ITGB3ITGA2B | |
| SCHEMBL9251361 | 0.76 | HDAC6 (0.55) | TP53HDAC6HDAC1HDAC8MAPT | |
| SCHEMBL9256145 | 0.75 | F2 (0.49) | ITGB3ITGA2B | |
| SCHEMBL9249490 | 0.75 | HDAC1 (0.56) | HDAC6HDAC1HDAC8PTGER4NAMPT | |
| SCHEMBL9248855 | 0.74 | ITGB3 (0.47) | HPGDHDAC6HDAC1HDAC8ALDH1A1 | |
| SCHEMBL9249572 | 0.73 | ITGB3 (0.56) | HDAC6HDAC1HDAC8PTGER4NAMPT | |
| SCHEMBL9251208 | 0.73 | ITGB3 (0.53) | PTGER4ITGB3ITGA2B | |
| SCHEMBL9255028 | 0.72 | ITGB3 (0.47) | HDAC6HDAC1HDAC8NAMPTITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5434150-A | Anticoagulants, cardiovascular disorders | DR. KARL THOMAE GMBH (DE) | 1995-07-18 | — | — | US | disclosed |
| EP-0531883-A1 | Condensed 5-membered ring heterocycles, process for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1993-03-17 | — | — | EP | disclosed |