SCHEMBL9252336

SCHEMBL9252336

Clc1ccccc1C=CCOCC=Cc1ccccc1Cl

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.45
NFE2L2 Q16236 5/20 0.44
RELA Q04206 1/20 0.44
GRIK1 P39086 1/20 0.42
GRIK2 Q13002 1/20 0.42
CHAT P28329 1/20 0.42
HDAC1 Q13547 1/20 0.42
HDAC8 Q9BY41 1/20 0.42
HDAC6 Q9UBN7 1/20 0.42
GSR P00390 1/20 0.42
KCNH2 Q12809 1/20 0.41
CYP1A2 P05177 2/20 0.41
CYP1A1 P04798 1/20 0.41
CYP1B1 Q16678 1/20 0.41
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
KDM4E B2RXH2 2/20 0.40
MAPT P10636 2/20 0.40
CYP2C9 P11712 1/20 0.40
HPGD P15428 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15549785 0.86 NFE2L2 (0.45) ALDH1A1NFE2L2RELAGRIK1GRIK2
SCHEMBL17093332 0.86 ALOX5 (0.47) ALDH1A1NFE2L2RELAGRIK1GRIK2
SCHEMBL30444298 0.86 NFE2L2 (0.45) ALDH1A1NFE2L2RELAGRIK1GRIK2
SCHEMBL15549783 0.86 NFE2L2 (0.45) ALDH1A1NFE2L2RELAGRIK1GRIK2
SCHEMBL15560209 0.86 ALOX5 (0.47) ALDH1A1NFE2L2RELAGRIK1GRIK2
SCHEMBL30443957 0.86 ALOX5 (0.47) ALDH1A1NFE2L2RELAGRIK1GRIK2
SCHEMBL28364836 0.84 NFE2L2 (0.44) ALDH1A1NFE2L2RELACHATKCNH2
SCHEMBL31018722 0.84 NFE2L2 (0.50) ALDH1A1NFE2L2RELAGRIK1GRIK2
SCHEMBL29137844 0.84 NFE2L2 (0.50) ALDH1A1NFE2L2RELAGRIK1GRIK2
SCHEMBL2091550 0.84 ALDH1A1 (0.47) ALDH1A1NFE2L2RELAGRIK1GRIK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5380654-A Process for the preparation of epoxides of means of microorganisms JAPAN ENERGY CORPORATION (JP) 1995-01-10 US claimed