Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | MGAM | O43451 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SI | P14410 | 1/20 | 0.47 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 7/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9253242 | 1.00 | ALOX5 (0.52) | ALOX5NPC1RAB9AGFERMGAM | |
| SCHEMBL9254559 | 0.88 | RAB9A (0.53) | NPC1RAB9ATP53LMNAMAPT | |
| SCHEMBL9254566 | 0.88 | RAB9A (0.53) | NPC1RAB9ATP53LMNAMAPT | |
| SCHEMBL9090789 | 0.88 | RAB9A (0.47) | ALOX5NPC1RAB9AGAATP53 | |
| SCHEMBL9090792 | 0.88 | RAB9A (0.47) | ALOX5NPC1RAB9AGAATP53 | |
| SCHEMBL9177189 | 0.87 | PPARG (0.53) | ALOX5GFERSCN9ATP53KCNH2 | |
| SCHEMBL9177195 | 0.87 | PPARG (0.53) | ALOX5GFERSCN9ATP53KCNH2 | |
| SCHEMBL9262429 | 0.85 | ALOX5 (0.48) | ALOX5NPC1RAB9ATP53LMNA | |
| SCHEMBL9262438 | 0.85 | ALOX5 (0.48) | ALOX5NPC1RAB9ATP53LMNA | |
| SCHEMBL9263735 | 0.84 | NPC1 (0.54) | ALOX5NPC1RAB9AGFERSCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5459154-A | Enzyme inhibitors as antiinflammatory agents and treatment of atherosclerosis | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-10-17 | — | — | US | disclosed |