Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.63 |
| ▸ | DRD3 | P35462 | 2/20 | 0.63 |
| ▸ | P2RX7 | Q99572 | 10/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.59 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4249527 | 0.95 | DRD3 (0.61) | DRD2DRD3P2RX7SIGMAR1ADRA1B | |
| SCHEMBL9836728 | 0.94 | DRD2 (0.67) | DRD2DRD3P2RX7SIGMAR1ADRA1B | |
| SCHEMBL20329228 | 0.92 | DRD3 (0.68) | DRD2DRD3 | |
| SCHEMBL10760285 | 0.89 | DRD2 (0.64) | DRD2DRD3P2RX7SIGMAR1ADRA1B | |
| SCHEMBL4249388 | 0.88 | LMNA (0.60) | DRD2DRD3P2RX7SIGMAR1ADRA1B | |
| SCHEMBL9253472 | 0.87 | DRD3 (0.66) | DRD2DRD3LMNA | |
| SCHEMBL9249869 | 0.84 | ACHE (0.68) | DRD2DRD3P2RX7ADRA1B | |
| SCHEMBL7381976 | 0.84 | DRD2 (0.68) | DRD2DRD3P2RX7ADRA1B | |
| SCHEMBL6617567 | 0.84 | DRD2 (0.63) | DRD2DRD3P2RX7ADRA1B | |
| SCHEMBL6163028 | 0.83 | HRH1 (0.64) | DRD2DRD3P2RX7LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487444-B9 | USE OF PYRIDYL AMIDES AS INHIBITORS OF ANGIOGENESIS | ASTELLAS DEUTSCHLAND GMBH (DE) | 2010-07-21 | — | — | EP | claimed |
| EP-1487444-B1 | USE OF PYRIDYL AMIDES AS INHIBITORS OF ANGIOGENESIS | ASTELLAS DEUTSCHLAND GMBH (DE) | 2009-12-30 | — | — | EP | claimed |
| US-5470851-A | Antihistamine, anticoagulants | SANKYO COMPANY, LIMITED (JP) | 1995-11-28 | — | — | US | disclosed |
| US-5166205-A | DERIVATIVES OF 1-DIPHENYLMETHYL PIPERAZINE AND THEIR USE AS ANTIHISTAMINES | LABORATORIOS DEL DR. ESTEVE, S. A. (ES) | 1992-11-24 | — | — | US | disclosed |
| EP-0298134-B1 | AROMATIC HETEROCYCLIC CARBOXYLIC ACID AMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | Dainippon Pharmaceutical Co., Ltd. (JP) | 1992-11-11 | — | — | EP | disclosed |
| EP-0496691-A1 | Diphenylmethylpiperazine derivatives | FABRICA ESPANOLA DE PRODUCTOS QUIMICOS Y FARMACEUTICOS, S.A. (FAES) (ES) | 1992-07-29 | — | — | EP | disclosed |
| EP-0468885-A1 | 1-Diphenylmethylpiperazine derivatives, their preparation, their use as medicines | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1992-01-29 | — | — | EP | disclosed |
| EP-0463873-A1 | Thiazolidinecarboxylic acid amide derivatives having anti-allergic activity, their preparation and their use | Sankyo Company Limited (JP) | 1992-01-02 | — | — | EP | disclosed |
| EP-0210782-B1 | PYRIDINE COMPOUNDS, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | Dainippon Pharmaceutical Co., Ltd. (JP) | 1991-04-17 | — | — | EP | disclosed |
| US-4965266-A | Antiallergens | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1990-10-23 | — | — | US | disclosed |
| EP-0298134-A1 | AROMATIC HETEROCYCLIC CARBOXYLIC ACID AMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | Dainippon Pharmaceutical Co., Ltd. (JP) | 1989-01-11 | — | — | EP | disclosed |
| US-4778796-A | ω-(3-pyridyl)alkenamide derivatives and anti-allergenic pharmaceutical compositions containing same | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1988-10-18 | — | — | US | disclosed |
| EP-0210782-A2 | Pyridine compounds, process for the preparation thereof and pharmaceutical composition containing the same | Dainippon Pharmaceutical Co., Ltd. (JP) | 1987-02-04 | — | — | EP | disclosed |