Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | TOP1 | P11387 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27672697 | 0.89 | NPC1 (0.64) | LMNAL3MBTL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL20191181 | 0.87 | TOP1 (0.62) | LMNAL3MBTL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7048480 | 0.83 | TOP1 (0.42) | LMNAL3MBTL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7371498 | 0.81 | VCAM1 (0.51) | LMNAMEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL7363637 | 0.78 | TPMT (0.56) | LMNAALDH1A1RAB9ATOP1GAA | |
| SCHEMBL4322943 | 0.76 | GAA (0.56) | LMNASMN1; SMN2HPGDALDH1A1CYP2C19 | |
| SCHEMBL8302813 | 0.76 | SMN1; SMN2 (0.60) | LMNAL3MBTL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7436807 | 0.76 | TPMT (0.43) | L3MBTL1MEN1KMT2ASMN1; SMN2HPGD | |
| SCHEMBL10318606 | 0.75 | ALDH1A1 (0.71) | LMNAL3MBTL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8848390 | 0.75 | MEN1 (0.55) | LMNAL3MBTL1MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1040062-C | Pharmacologically active compounds, methods for the preparing thereof and compositions containing same | ORION YHTYMAE OY (FI) | 1998-10-07 | — | — | CN | disclosed |
| US-5446194-A | Pharmacologically active catechol derivatives | ORION-YHTYMA OY (FI) | 1995-08-29 | — | — | US | disclosed |
| US-5283352-A | Transferase inhibitor | ORION-YHTYMA OY (FI) | 1994-02-01 | — | — | US | disclosed |
| US-5112861-A | Inhibitors of catechol-methyl-transferase enzyme, levodopa | ORION-YHTYMA OY (FI) | 1992-05-12 | — | — | US | disclosed |
| US-4963590-A | ENZYME INHIBITOR FOR TREATING PARKINSON'S DISEASE ALONG WITH DOPA;POTENTIATION | ORION-YHTYMA OY (FI) | 1990-10-16 | — | — | US | disclosed |