Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 0.52 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9261012 | 0.77 | ACACB (0.49) | ALOX5 | |
| SCHEMBL18641560 | 0.75 | CYP11B1 (0.50) | CYP11B1NPC1ALDH1A1RAB9AMAPT | |
| SCHEMBL2468247 | 0.75 | ALDH1A1 (0.53) | CYP11B1NPC1ALDH1A1RAB9AMAPT | |
| SCHEMBL9373624 | 0.75 | CYP2E1 (0.53) | ALOX5RAB9AHDAC1HDAC2HDAC3 | |
| SCHEMBL9253369 | 0.74 | ALOX5 (0.59) | ALOX5CYP11B1NPC1ALDH1A1RAB9A | |
| SCHEMBL3492794 | 0.73 | CYP11B1 (0.53) | CYP11B1NPC1ALDH1A1RAB9AMAPT | |
| SCHEMBL1895825 | 0.73 | CYP11B1 (0.56) | CYP11B1NPC1ALDH1A1RAB9AMAPT | |
| SCHEMBL1567261 | 0.73 | HDAC1 (0.59) | CYP11B1NPC1ALDH1A1RAB9AMAPT | |
| SCHEMBL5658371 | 0.72 | FEN1 (0.38) | CYP11B1NPC1ALDH1A1RAB9AMAPT | |
| SCHEMBL21229053 | 0.72 | HDAC1 (0.51) | CYP11B1NPC1ALDH1A1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5464849-A | N-hydroxyurea derivatives as antiallergy and antiinflammatory agents | PFIZER INC. (US) | 1995-11-07 | — | — | US | claimed |
| EP-0566593-A1 | N-HYDROXYUREA DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1993-10-27 | — | — | EP | claimed |
| WO-1992012141-A1 | N-HYDROXYUREA DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1992-07-23 | — | — | WO | claimed |
| US-5464849-A | N-hydroxyurea derivatives as antiallergy and antiinflammatory agents | PFIZER INC. (US) | 1995-11-07 | — | — | US | disclosed |
| EP-0566593-A1 | N-HYDROXYUREA DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1993-10-27 | — | — | EP | disclosed |
| WO-1992012141-A1 | N-HYDROXYUREA DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1992-07-23 | — | — | WO | disclosed |