Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.48 |
| ▸ | RXRB | P28702 | 2/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.41 |
| ▸ | RXRG | P48443 | 1/20 | 0.41 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | RARB | P10826 | 1/20 | 0.39 |
| ▸ | RARG | P13631 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9263173 | 0.99 | RXRA (0.47) | RXRARXRBNR4A2HDAC6CYP26A1 | |
| SCHEMBL9260521 | 0.89 | HDAC6 (0.48) | HDAC6NR1H4ADAM17EPHX2LMNA | |
| SCHEMBL9263178 | 0.89 | HDAC6 (0.46) | RXRARXRBNR4A2HDAC6NR1H4 | |
| SCHEMBL9259605 | 0.88 | NR4A2 (0.53) | NR4A2HDAC6CYP26A1CYP26B1NR1H4 | |
| SCHEMBL9260238 | 0.85 | RXRA (0.45) | RXRARXRBNR4A2HDAC6NR1H4 | |
| SCHEMBL9255594 | 0.84 | HDAC6 (0.42) | RXRARXRBNR4A2HDAC6CYP26A1 | |
| SCHEMBL9262883 | 0.83 | HDAC6 (0.43) | RXRARXRBNR4A2HDAC6NR1H4 | |
| SCHEMBL9251869 | 0.83 | CYP26A1 (0.49) | RXRARXRBCYP26A1CYP3A4CYP26B1 | |
| SCHEMBL9259950 | 0.83 | NR4A2 (0.47) | RXRARXRBNR4A2CYP26A1CYP3A4 | |
| SCHEMBL9260016 | 0.83 | HDAC6 (0.43) | RXRARXRBNR4A2HDAC6NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5432195-A | Anticholesterol | NIPPON SHINYAKU COMPANY LIMITED (JP) | 1995-07-11 | — | — | US | claimed |
| US-5432195-A | Anticholesterol | NIPPON SHINYAKU COMPANY LIMITED (JP) | 1995-07-11 | — | — | US | disclosed |
| EP-0601181-A1 | BENZOFURAN DERIVATIVE AND PHARMACEUTICAL COMPOSITION | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1994-06-15 | — | — | EP | disclosed |