Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 2/20 | 0.50 |
| ▸ | MGLL | Q99685 | 2/20 | 0.50 |
| ▸ | MPO | P05164 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9255506 | 0.84 | KMT2A (0.58) | PHGDHMGLLALDH1A1KDM4ELMNA | |
| SCHEMBL9250088 | 0.84 | MPO (0.65) | PHGDHMGLLMPOALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL9248600 | 0.83 | ALDH1A1 (0.56) | PHGDHMGLLALDH1A1KDM4ELMNA | |
| SCHEMBL9252188 | 0.83 | ATM (0.58) | PHGDHMGLLALDH1A1FAAHKDM4E | |
| SCHEMBL9255782 | 0.83 | PHGDH (0.50) | PHGDHMGLLMPOALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL9250779 | 0.82 | PHGDH (0.49) | PHGDHMGLLMPOALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL9253120 | 0.82 | ATM (0.57) | PHGDHMGLLALDH1A1FAAHKDM4E | |
| SCHEMBL9253789 | 0.81 | PHGDH (0.48) | PHGDHMGLLMPOALDH1A1HPGD | |
| SCHEMBL9253004 | 0.81 | LMNA (0.58) | PHGDHALDH1A1KDM4ELMNAMAPT | |
| Hydrochloric Acid SCHEMBL9252823 | 0.80 | LMNA (0.57) | PHGDHALDH1A1KDM4ELMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5446146-A | Treatment of liver disorders | NIPPON CHEMIPHAR CO., LTD. (JP) | 1995-08-29 | — | — | US | disclosed |
| EP-0326379-B1 | Therapeutic agent for liver disease and piperazine derivatives | NIPPON CHEMIPHAR CO (JP) | 1994-06-01 | — | — | EP | disclosed |
| US-5070089-A | INHIBITION OF LIPID PEROXIDATION | NIPPON CHEMIPHAR CO., LTD. (JP) | 1991-12-03 | — | — | US | disclosed |
| EP-0326379-A2 | Therapeutic agent for liver disease and piperazine derivatives | NIPPON CHEMIPHAR CO., LTD. (JP) | 1989-08-02 | — | — | EP | disclosed |