Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9253264 | 0.83 | ALDH1A1 (0.49) | ALDH1A1KMT2AMEN1MAPTPOLB | |
| SCHEMBL5396736 | 0.81 | ALDH1A1 (0.52) | ALDH1A1KMT2AMEN1POLBTGFBR1 | |
| SCHEMBL19002662 | 0.77 | TP53 (0.50) | ALDH1A1KMT2APOLBTGFBR1ACVR1 | |
| SCHEMBL9247077 | 0.77 | KDM4E (0.62) | ALDH1A1KMT2AMEN1POLBLMNA | |
| SCHEMBL19002660 | 0.77 | KMT2A (0.53) | KMT2AMEN1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL9829916 | 0.77 | ALDH1A1 (0.55) | ALDH1A1KMT2AMEN1MAPTPOLB | |
| SCHEMBL10690642 | 0.75 | ALDH1A1 (0.53) | ALDH1A1KMT2AMEN1MAPTPOLB | |
| SCHEMBL27953331 | 0.74 | LMNA (0.54) | ALDH1A1KMT2AMEN1MAPTPOLB | |
| SCHEMBL26186618 | 0.73 | POLB (0.69) | ALDH1A1KMT2AMEN1MAPTPOLB | |
| SCHEMBL16276134 | 0.73 | LMNA (0.63) | ALDH1A1POLBCYP1A2L3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5446146-A | Treatment of liver disorders | NIPPON CHEMIPHAR CO., LTD. (JP) | 1995-08-29 | — | — | US | disclosed |
| EP-0326379-B1 | Therapeutic agent for liver disease and piperazine derivatives | NIPPON CHEMIPHAR CO (JP) | 1994-06-01 | — | — | EP | disclosed |
| US-5070089-A | INHIBITION OF LIPID PEROXIDATION | NIPPON CHEMIPHAR CO., LTD. (JP) | 1991-12-03 | — | — | US | disclosed |
| EP-0326379-A2 | Therapeutic agent for liver disease and piperazine derivatives | NIPPON CHEMIPHAR CO., LTD. (JP) | 1989-08-02 | — | — | EP | disclosed |