Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.57 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.57 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.57 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.57 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | KDM1A | O60341 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL27408001 | 0.98 | HPGD (0.56) | HPGDLMNAHDAC3HDAC4HDAC1 | |
| SCHEMBL31112221 | 0.85 | LMNA (0.54) | HPGDLMNAHDAC3HDAC4HDAC1 | |
| SCHEMBL8090581 | 0.82 | KDM1A (0.51) | HPGDLMNAHDAC3HDAC4HDAC1 | |
| SCHEMBL5145094 | 0.82 | HPGD (0.51) | HPGDLMNAHDAC3HDAC4HDAC1 | |
| SCHEMBL8090578 | 0.82 | KDM1A (0.51) | HPGDLMNAHDAC3HDAC4HDAC1 | |
| SCHEMBL29012005 | 0.81 | MAPT (0.57) | HPGDLMNAHDAC3HDAC4HDAC1 | |
| SCHEMBL20893427 | 0.81 | KMT2A (0.54) | HPGDLMNAMAPTTSHRALDH1A1 | |
| SCHEMBL6765899 | 0.81 | BCHE (0.54) | LMNAHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL13373760 | 0.81 | ALDH1A1 (0.56) | HPGDLMNAHDAC3HDAC4HDAC1 | |
| SCHEMBL1689206 | 0.81 | EPHX2 (0.68) | HDAC3HDAC4HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 246 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118666706-A | Preparation method of atorvastatin calcium mother nucleus | 上海应用技术大学 | 2024-09-20 | — | — | CN | claimed |
| CN-115466196-B | Preparation method of atorvastatin calcium intermediate | 宿迁阿尔法科技有限公司 | 2024-03-26 | — | — | CN | claimed |
| CN-117695992-A | Full-continuous chemical synthesis device and method for atorvastatin calcium mother nucleus | 复旦大学 | 2024-03-15 | — | — | CN | claimed |
| CN-113788766-B | Preparation method of atorvastatin calcium intermediate | 江苏阿尔法集团盛基药业(宿迁)有限公司 | 2024-01-12 | — | — | CN | claimed |
| CN-113816867-B | Method for preparing atorvastatin calcium intermediate by continuous flow tubular reactor | 江苏阿尔法集团盛基药业(宿迁)有限公司 | 2024-01-12 | — | — | CN | claimed |
| CN-114295768-B | Determination method for 10 impurities in atorvastatin mother nucleus M4 | 河南豫辰药业股份有限公司 | 2023-09-12 | — | — | CN | claimed |
| CN-113896646-B | Efficient green preparation method of 4-methyl-3-oxo-N-phenyl valeramide | 浙江海森药业股份有限公司 | 2023-06-02 | — | — | CN | claimed |
| CN-115466196-A | Preparation method of atorvastatin calcium intermediate | 宿迁阿尔法科技有限公司 | 2022-12-13 | — | — | CN | claimed |
| CN-115260051-A | Preparation process of atorvastatin calcium intermediate | 江苏阿尔法药业股份有限公司 | 2022-11-01 | — | — | CN | claimed |
| CN-114295768-A | Method for determining 10 impurities in atorvastatin mother nucleus M4 | 河南豫辰药业股份有限公司 | 2022-04-08 | — | — | CN | claimed |
| CN-101307009-A | New synthetic method for (earth)4-fluor-alpha-(2-methyl-1-oxypropyl )-gamma-oxo-N, beta-diphenyl benzene butanamide | ZHEJIANG JINGXIN PHARMACEUTICA (CN) | 2008-11-19 | — | — | CN | claimed |
| CN-101250133-A | Novel method for synthesizing (+/-)p-fluoro-2-(2-methyl-propionyl)-4-oxygen-N,3-diphenyl-benzenebutanamide and intermediate therein | INST MATERIA MEDICA CAMS (CN) | 2008-08-27 | — | — | CN | claimed |
| CN-1325844-A | Novel synthesis method of (+/-) p-fluoro-2- (2-methyl-propionyl) -4-oxo-N, 3-diphenyl-phenylbutylamide and intermediate thereof | INST OF MEDICAL MATERIALS CHIN (CN) | 2001-12-12 | — | — | CN | claimed |
| EP-0330172-B1 | Improved process for trans-6-[2-(substituted-pyrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis | WARNER LAMBERT CO (US) | 1994-08-10 | — | — | EP | claimed |
| US-5216174-A | Process for trans-6-[12-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis | WARNER-LAMBERT CO. (US) | 1993-06-01 | — | — | US | claimed |
| WO-1993002043-A1 | DIMETHYLACETOACETAMIDES, METHODS OF PREPARING THEM, AND DRUGS CONTAINING THEM | LUITPOLD PHARMA GMBH (DE) | 1993-02-04 | — | — | WO | claimed |
| EP-0525686-A1 | Dimethylacetylacetic acid amides, process for their preparation and pharmaceutical compositions | LUITPOLD PHARMA GmbH (DE) | 1993-02-03 | — | — | EP | claimed |
| EP-0448552-A1 | IMPROVED PROCESS FOR $i(TRANS)-6- 2-(SUBSTITUTED-PYRROL-1-YL)ALKYL]PYRAN-2-ONE INHIBITORS OF CHOLESTEROL SYNTHESIS | WARNER-LAMBERT COMPANY (US) | 1991-10-02 | — | — | EP | claimed |
| EP-0330172-A2 | Improved process for trans-6-[2-(substituted-pyrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis | WARNER-LAMBERT COMPANY (US) | 1989-08-30 | — | — | EP | claimed |
| WO-1989007598-A2 | IMPROVED PROCESS FOR TRANS-6-[2-(SUBSTITUTED-PYRROL-1-YL)ALKYL]PYRAN-2-ONE INHIBITORS OF CHOLESTEROL SYNTHESIS | WARNER-LAMBERT COMPANY (US) | 1989-08-24 | — | — | WO | claimed |