Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 7/20 | 0.39 |
| ▸ | AGTR2 | P50052 | 7/20 | 0.39 |
| ▸ | BDKRB1 | P46663 | 8/20 | 0.38 |
| ▸ | PPIA | P62937 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9255659 | 0.90 | BRS3 (0.40) | AGTR1AGTR2BDKRB1 | |
| SCHEMBL6609722 | 0.77 | HTT (0.41) | HTTAGTR1AGTR2BDKRB1PPIA | |
| SCHEMBL6607743 | 0.77 | HTT (0.41) | HTTAGTR1AGTR2BDKRB1PPIA | |
| SCHEMBL9256905 | 0.76 | AGTR1 (0.59) | AGTR1AGTR2 | |
| SCHEMBL1523210 | 0.74 | HTT (0.61) | HTTPPIAHSD17B10 | |
| SCHEMBL8826228 | 0.73 | HTT (0.47) | HTTPPIAHSD17B10 | |
| SCHEMBL8944331 | 0.71 | AGTR1 (0.51) | AGTR1AGTR2 | |
| SCHEMBL8944158 | 0.70 | JMJD6 (0.39) | AGTR1AGTR2 | |
| SCHEMBL8944447 | 0.69 | AGTR1 (0.36) | AGTR1AGTR2 | |
| SCHEMBL9596670 | 0.68 | HTT (0.46) | HTTPPIAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5459148-A | Cardiovascular disorders | SANKYO COMPANY, LIMITED (JP) | 1995-10-17 | — | — | US | disclosed |
| EP-0603001-A1 | Biphenyl derivatives, their preparation and their use for the treatment of hypertension and cardiac disease | SANKYO COMPANY LIMITED (JP) | 1994-06-22 | — | — | EP | disclosed |