Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JMJD6 | Q6NYC1 | 2/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 7/20 | 0.38 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6610008 | 0.91 | AGTR1 (0.39) | JMJD6AGTR1AGTR2TP53 | |
| SCHEMBL8944450 | 0.84 | LMNA (0.39) | AGTR1AGTR2TP53NPSR1 | |
| SCHEMBL8944331 | 0.84 | AGTR1 (0.51) | AGTR1AGTR2TSHRMAPK1NPSR1 | |
| SCHEMBL8944447 | 0.83 | AGTR1 (0.36) | AGTR1AGTR2TP53MAPK1 | |
| SCHEMBL8551396 | 0.79 | AGTR1 (0.38) | JMJD6AGTR1AGTR2TP53 | |
| SCHEMBL8548779 | 0.77 | LTB4R2 (0.48) | JMJD6AGTR1AGTR2 | |
| SCHEMBL8944162 | 0.76 | AGTR1 (0.54) | AGTR1AGTR2 | |
| SCHEMBL6608520 | 0.73 | JMJD6 (0.39) | JMJD6TSHRMAPK1NPSR1 | |
| SCHEMBL6604865 | 0.70 | AGTR1 (0.43) | AGTR1AGTR2 | |
| SCHEMBL8548756 | 0.68 | AGTR1 (0.37) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5500427-A | ANGIOTENSIN II ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-03-19 | — | — | US | disclosed |