Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.40 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 4/20 | 0.39 |
| ▸ | MMP3 | P08254 | 2/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.38 |
| ▸ | ITGAV | P06756 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9258643 | 0.88 | KMT2A (0.50) | KMT2A | |
| SCHEMBL9260639 | 0.85 | ALDH1A1 (0.42) | CYP3A4HPGDCYP2C19RAB9AKMT2A | |
| SCHEMBL9256395 | 0.80 | MAPT (0.47) | MAPTCYP3A4GABBR2GABBR1KDM4E | |
| SCHEMBL9261597 | 0.78 | GABBR2 (0.51) | MAPTCYP3A4CYP2C19GABBR2GABBR1 | |
| SCHEMBL9261314 | 0.78 | PTGIR (0.42) | MAPTGABBR2GABBR1KDM4ERECQL | |
| SCHEMBL9262490 | 0.78 | MAPT (0.45) | MAPTGABBR2GABBR1KDM4ERECQL | |
| SCHEMBL7655013 | 0.78 | MAPT (0.55) | MAPTCYP3A4CYP2C19GABBR2GABBR1 | |
| SCHEMBL9257263 | 0.77 | KMT2A (0.46) | KDM4EKMT2A | |
| SCHEMBL9255965 | 0.76 | CYP1A2 (0.44) | MAPTSSTR4 | |
| SCHEMBL9262569 | 0.74 | SMN1; SMN2 (0.44) | MAPTRAB9AITGB3ITGAVKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5393875-A | Hypotensive, cardiotonic and antiischemic agents | HOFFMANN-LA ROCHE INC. (US) | 1995-02-28 | — | — | US | disclosed |