SCHEMBL9257732

SCHEMBL9257732

Cc1c(N2CCC(N)C2)c(F)cc2c(=O)c(C(=O)O)cn(C3COC3)c12

nearest known ligand 0.68

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.68
POLB P06746 1/20 0.68
CHRM2 P08172 1/20 0.68
CHRM1 P11229 1/20 0.68
OPRM1 P35372 1/20 0.68
OPRD1 P41143 1/20 0.68
KCNH2 Q12809 5/20 0.67
TOP2A P11388 12/20 0.55
TOP2B Q02880 10/20 0.55
TOP1 P11387 2/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9023327 0.93 ALDH1A1 (0.79) ALDH1A1POLBCHRM2CHRM1OPRM1
SCHEMBL9047082 0.93 ALDH1A1 (0.79) ALDH1A1POLBCHRM2CHRM1OPRM1
SCHEMBL9266342 0.89 KCNH2 (0.69) ALDH1A1POLBCHRM2CHRM1OPRM1
SCHEMBL4365471 0.87 KCNH2 (0.73) ALDH1A1POLBCHRM2CHRM1OPRM1
SCHEMBL12012672 0.86 KCNH2 (0.70) ALDH1A1POLBCHRM2CHRM1OPRM1
SCHEMBL1387312 0.85 ALDH1A1 (0.82) ALDH1A1POLBCHRM2CHRM1OPRM1
SCHEMBL9416082 0.85 ALDH1A1 (0.82) ALDH1A1POLBCHRM2CHRM1OPRM1
SCHEMBL9416068 0.85 ALDH1A1 (0.82) ALDH1A1POLBCHRM2CHRM1OPRM1
SCHEMBL10571361 0.85 KCNH2 (0.73) ALDH1A1POLBCHRM2CHRM1OPRM1
Hydrochloric Acid SCHEMBL8566510 0.84 ALDH1A1 (0.80) ALDH1A1POLBCHRM2CHRM1OPRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5407932-A Bactericides WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) 1995-04-18 US disclosed
EP-0393400-B1 Novel quinolone derivatives, preparation processes thereof, and antibacterial agents containing the same WAKUNAGA SEIYAKU KK (JP) 1994-12-21 EP disclosed
US-5245037-A Synthetic bactericides WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) 1993-09-14 US disclosed
EP-0393400-A1 Novel quinolone derivatives, preparation processes thereof, and antibacterial agents containing the same WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) 1990-10-24 EP disclosed