Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 8/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9258199 | 0.78 | AKR1B1 (0.45) | STAT3AKR1B1GABRA1GABRB2CDK2 | |
| SCHEMBL6548544 | 0.75 | F10 (0.52) | STAT3CDK2F10CA12CA1 | |
| SCHEMBL9253769 | 0.74 | GABRA1 (0.41) | AKR1B1GABRA1GABRB2CDK2CA12 | |
| SCHEMBL9258217 | 0.74 | HSD17B10 (0.35) | GABRA1GABRB2CA12CA1CA2 | |
| SCHEMBL6009677 | 0.74 | GABRA1 (0.47) | AKR1B1GABRA1GABRB2CA12CA1 | |
| SCHEMBL8657376 | 0.72 | ABL1 (0.53) | STAT3CDK2F10CA12CA1 | |
| SCHEMBL9258213 | 0.71 | LDHA (0.42) | STAT3AKR1B1GABRA1GABRB2CA12 | |
| SCHEMBL9258201 | 0.71 | CYP2C9 (0.35) | GABRA1GABRB2CA12CA1CA2 | |
| SCHEMBL29438375 | 0.70 | PDE4A (0.43) | STAT3CDK2F10CA12CA1 | |
| SCHEMBL4906156 | 0.69 | POLB (0.44) | STAT3AKR1B1GABRA1GABRB2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0479332-B1 | Diphenyl-methane derivative, pharmaceutical composition and use | EISAI CO LTD (JP) | 1995-06-21 | — | — | EP | disclosed |
| US-5206403-A | Diphenylethylene derivatives, pharmaceutical compositions containing same and treatment methods | EISAI CO., LTD. (JP) | 1993-04-27 | — | — | US | disclosed |
| US-5182301-A | Anticoagulants | EISAI CO., LTD. (JP) | 1993-01-26 | — | — | US | disclosed |
| EP-0479332-A2 | Diphenyl-methane derivative, pharmaceutical composition and use | Eisai Co., Ltd. (JP) | 1992-04-08 | — | — | EP | disclosed |
| US-5103010-A | DIPHENYLETHYLENE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND TREATMENT METHOD | EISAI CO., LTD. (JP) | 1992-04-07 | — | — | US | disclosed |
| EP-0478001-A1 | Benzophenone oxime derivatives, pharmaceutical compositions and use | Eisai Co., Ltd. (JP) | 1992-04-01 | — | — | EP | disclosed |
| US-5064848-A | Anticoagulants | EISAI CO., LTD. (JP) | 1991-11-12 | — | — | US | disclosed |
| US-5034418-A | Anticoagulants | EISAI CO., LTD. (JP) | 1991-07-23 | — | — | US | disclosed |
| US-4978767-A | ANTICOAGULANTS | EISAI CO., LTD. (JP) | 1990-12-18 | — | — | US | disclosed |
| US-4886834-A | ANTICOAGULANTS | EISAI CO., LTD. (JP) | 1989-12-12 | — | — | US | disclosed |
| EP-0238973-A2 | Diphenyl-methane derivative, pharmaceutical composition and use | Eisai Co., Ltd. (JP) | 1987-09-30 | — | — | EP | disclosed |