Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | THRA | P10827 | 1/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2056251 | 0.93 | THRA (0.62) | POLBTHRATHRBPRSS1LMNA | |
| SCHEMBL16958052 | 0.90 | PRSS1 (0.58) | POLBTHRATHRBPRSS1LMNA | |
| SCHEMBL177201 | 0.89 | PLA2G4B (0.65) | THRATHRBPRSS1PLA2G4BMAPT | |
| SCHEMBL2339687 | 0.88 | POLB (0.73) | POLBLMNAALDH1A1SMN1; SMN2GAA | |
| SCHEMBL28941511 | 0.87 | THRA (0.56) | POLBTHRATHRBPRSS1LMNA | |
| SCHEMBL3743030 | 0.86 | PRSS1 (0.61) | POLBTHRATHRBPRSS1LMNA | |
| SCHEMBL11790540 | 0.86 | ALDH1A1 (0.56) | POLBTHRATHRBPRSS1LMNA | |
| SCHEMBL566268 | 0.86 | THRA (0.55) | POLBTHRATHRBPRSS1LMNA | |
| SCHEMBL16958893 | 0.85 | PRSS1 (0.53) | POLBTHRATHRBPRSS1LMNA | |
| SCHEMBL5913385 | 0.85 | THRA (0.60) | POLBTHRATHRBPRSS1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016001452-A1 | COMPOUNDS, IN PARTICULAR FOR USE IN THE TREATMENT OF A DISEASE OR CONDITION FOR WHICH A BROMODOMAIN INHIBITOR IS INDICATED | Universität Zürich (CH) | 2016-01-07 | — | — | WO | disclosed |
| US-5410064-A | Thromboxane A2 antagonists and inhibitors of thromboxane A2 synthase | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-04-25 | — | — | US | disclosed |