Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 6/20 | 0.49 |
| ▸ | CRHR1 | P34998 | 4/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | S100A4 | P26447 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GPR3 | P46089 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28803407 | 0.86 | HSD11B1 (0.47) | HSD11B1CRHR1AHRNPC1ALDH1A1 | |
| SCHEMBL9258401 | 0.85 | PTPN1 (0.42) | HSD11B1ALDH1A1KDM4ES100A4TSHR | |
| SCHEMBL9261398 | 0.82 | CYP2A6 (0.44) | HSD11B1NPC1ALDH1A1HPGDRAB9A | |
| SCHEMBL12618386 | 0.81 | CYP3A4 (0.44) | HSD11B1HPGDSMN1; SMN2S100A4TSHR | |
| SCHEMBL21652293 | 0.81 | PDK2 (0.40) | HSD11B1NPC1ALDH1A1RAB9ATSHR | |
| SCHEMBL9257716 | 0.80 | HSD11B1 (0.43) | HSD11B1ALDH1A1S100A4TSHRTDP1 | |
| SCHEMBL9254227 | 0.80 | TRPV4 (0.42) | HSD11B1CRHR1NPC1ALDH1A1KDM4E | |
| SCHEMBL29416163 | 0.78 | AHR (0.52) | HSD11B1CRHR1AHRNPC1ALDH1A1 | |
| SCHEMBL2934558 | 0.78 | AHR (0.52) | HSD11B1CRHR1AHRNPC1ALDH1A1 | |
| SCHEMBL11020611 | 0.77 | ALDH1A1 (0.50) | HSD11B1NPC1ALDH1A1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120135997-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A LACTAM OR BENZENESULFONAMIDE COMPOUND | SHIONOGI & CO., LTD. (JP) | 2012-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120135997-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A LACTAM OR BENZENESULFONAMIDE COMPOUND | BACE1, STS, APP | HSD11B1 702/4885CRHR1 4139/4885AHR 987/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.