Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 4/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.46 |
| ▸ | P2RY12 | Q9H244 | 4/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8883490 | 0.77 | NFE2L2 (0.44) | PDE3BPDE3AP2RY12KEAP1NFE2L2 | |
| SCHEMBL9002571 | 0.77 | PDE3B (0.48) | PDE3BPDE3AP2RY12KEAP1NFE2L2 | |
| SCHEMBL8883481 | 0.76 | KEAP1 (0.44) | PDE3BPDE3AP2RY12KEAP1NFE2L2 | |
| SCHEMBL5958925 | 0.72 | NCF1 (0.51) | NPC1MAPTRAB9ANCF1CYSLTR1 | |
| SCHEMBL11598868 | 0.71 | NFE2L2 (0.56) | KEAP1NFE2L2HTTNPC1RAB9A | |
| SCHEMBL11272215 | 0.70 | MAOB (0.59) | PDE3BPDE3ATSHR | |
| SCHEMBL8630145 | 0.69 | KEAP1 (0.60) | KEAP1NFE2L2HTTNPC1RAB9A | |
| SCHEMBL9187143 | 0.69 | MAOB (0.42) | MAPTMCL1 | |
| SCHEMBL9190037 | 0.69 | MCL1 (0.43) | KEAP1NFE2L2HTTNPC1MAPT | |
| SCHEMBL10834659 | 0.69 | MAOB (0.46) | PDE3BPDE3AP2RY12KEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5426119-A | Thromboxane antagonists | DR. KARL THOMAE GMBH (DE) | 1995-06-20 | — | — | US | disclosed |
| US-5294626-A | Thromboxane synthesis inhibitors and anticoagulants | DR. KARL THOMAS GMBH (DE) | 1994-03-15 | — | — | US | disclosed |