Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | CCR4 | P51679 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.33 |
| ▸ | ALB | P02768 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12844161 | 0.82 | SLC6A3 (0.40) | KMT2AMEN1POLBRAB9AALDH1A1 | |
| SCHEMBL2644081 | 0.79 | KMT2A (0.38) | KMT2AMEN1POLBRAB9AALDH1A1 | |
| SCHEMBL2628923 | 0.79 | KMT2A (0.44) | KMT2AMEN1POLBRAB9AALDH1A1 | |
| SCHEMBL13986776 | 0.79 | MEN1 (0.38) | KMT2AMEN1POLBRAB9AALDH1A1 | |
| SCHEMBL12120609 | 0.79 | ALDH1A1 (0.40) | KMT2AMEN1POLBRAB9AALDH1A1 | |
| SCHEMBL5779345 | 0.79 | KMT2A (0.38) | KMT2AMEN1POLBRAB9AALDH1A1 | |
| SCHEMBL5779031 | 0.79 | KMT2A (0.38) | KMT2AMEN1POLBRAB9AALDH1A1 | |
| SCHEMBL12776037 | 0.76 | KMT2A (0.36) | KMT2AMEN1POLBRAB9AALDH1A1 | |
| SCHEMBL13986777 | 0.76 | KMT2A (0.36) | KMT2AMEN1POLBRAB9AALDH1A1 | |
| SCHEMBL12190528 | 0.76 | MEN1 (0.34) | KMT2AMEN1POLBRAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5399702-A | Leukotriene antagonists; antiasthmatic, antiallergen, and antianaphylactic agents | HOFFMANN-LA ROCHE INC. (US) | 1995-03-21 | — | — | US | disclosed |
| CN-1087086-A | Thiazolylvinylphenyl derivatives | HOFFMANN LA ROCHE (CH) | 1994-05-25 | — | — | CN | disclosed |
| EP-0577003-A1 | Thiazolylvinylphenyl derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1994-01-05 | — | — | EP | disclosed |
| US-5273986-A | A substituted phenylalkyleneamidophenyleneethylene thiazole | HOFFMANN-LA ROCHE INC. (US) | 1993-12-28 | — | — | US | disclosed |